| Identification | Back Directory | [Name]
2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER | [CAS]
118-57-0 | [Synonyms]
SALOPHEN
Asalphen
Cetosalol
Phenestal
Phenetsal
acetaminosalol
p-Acetamidophenyl salicylate
4-acetamidophenyl salicylate
4-Acetaminophenyl salicylate
ACETYL-P-AMINOPHENYLSALICYLATE
Salicylic acid 4-(acetylamino)phenyl
(4-acetamidophenyl) 2-hydroxybenzoate
Salicylic acid 4-(acetylamino)phenyl ester
2-hydroxybenzoic acid (4-acetamidophenyl) ester
2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER | [EINECS(EC#)]
204-261-3 | [Molecular Formula]
C15H13NO4 | [MDL Number]
MFCD00020033 | [MOL File]
118-57-0.mol | [Molecular Weight]
271.27 |
| Hazard Information | Back Directory | [Chemical Properties]
solid | [Originator]
Acetaminosal ,ZYF Pharm Chemical | [Uses]
Analgesic; antipyretic. | [Definition]
ChEBI: Acetaminosalol is a carbonyl compound. | [Manufacturing Process]
2 Methods of producing of acetyl salicylic acid ester of N-acetyl-paminophenol:
1. 65.0 g of N-acetyl-p-aminophenol were slurried with 400 ml of water and
cooled to 10°C. 125 ml of 20% sodium hydroxide were slowly added to the
mixture with stirring, the temperature being maintained 10°-15°C. To the
solution obtained, 75.0 g of acetyl salicylic chloride were added with vigorous
stirring over a period of 0.5 h, the solution being maintained at a temperature of about 10°C. Towards the end of the reaction the pH was checked and
adjusted to greater than 10 by the addition of a small amount of 20% sodium
hydroxide. After all the acid chloride had been added, vigorous stirring was
continued for 0.5 h during which time the crude product separated out. The
acetyl salicylic acid ester of N-acetyl-p-aminophenol was filtered off, washed
thoroughly with water and recrystallised from ethanol.
2. 65.0 g of sodium N-acetyl-p-aminophenol were slurried with 500.0 g of dry
benzene and 80.0 g of acetyl salicylic chloride added. The mixture was heated
under reflux for 4 h and filtered hot. The excess benzene was removed under
vacuum and the crude acetyl salicylic acid ester of N-acetyl-p-aminophenol
crystallized from ethanol. | [Brand name]
Acephen (G & W);
Infants’ Feverall (Actavis); Injectapap (Ortho-McNeil);
Neopap (Polymedica); Tylenol (McNeil). | [Therapeutic Function]
Analgesic, Antineuralgic, Antirheumatic, Antipyretic |
|
| Company Name: |
SynAsst Chemical.
|
| Tel: |
021-60343070 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15848/0.htm |
| Company Name: |
Trigona oHG
|
| Tel: |
+49 611 962 5283 |
| Website: |
www.trigona.de |
| Company Name: |
Camida
|
| Tel: |
+353-52-25455 |
| Website: |
www.camida.com |
| Company Name: |
Eastern Chemical Corp.
|
| Tel: |
631 273-0900 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList159/0_EN.htm |
|