| Identification | Back Directory | [Name]
PTEROIC ACID | [CAS]
119-24-4 | [Synonyms]
NSC 14972
PTEROIC ACID
Pyrofolic acid
Pteroic Acid (>
Pteroic acid >=93%
Pteroic Acid (>85%)
Pteroic acid - min95%
Folic acid iMpurity D
Folic Acid Impurity 6
Folic acid EP Impurity D
PTEROIC ACID HYDRATE, 90%
Folic acid impurity D CRS
Pteroic acid(Instant type)
Folic acid iMpurity D
Pteroic acid
4-[[(2-Amino-4-oxo-1,4-dihydropteri
4-(((2-amino-4-hydroxypteridin-6-yl)
4-(((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)
Methotrexate EP Impurity D Desmethyl Impurity
Folic Acid Impurity 6（Folic Acid EP Impurity D）
Methotrexate EP Impurity D N-Desmethyl Impurity
p-[(2-AMino-4-hydroxy-6-pteridylMethyl)aMino]benzoic Acid
4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoic acid
p-((2-amino-4-hydroxypteridin-6-yl)methylamino)benzoic acid
4-[(2-azanyl-4-oxo-1H-pteridin-6-yl)methylamino]benzoic acid
4-[(2-amino-4-keto-1H-pteridin-6-yl)methylamino]benzoic acid
4-{[(2-Amino-4-hydroxypteridin-6-yl)methyl]amino}benzoic acid
4-[[(2-AMino-3,4-dihydro-4-oxo-6-pteridinyl)Methyl]aMino]benzoic Acid
4-(((2-AMino-4-oxo-3,4-dihydropteridin-6-yl)Methyl)aMino)benzoic acid
Benzoic acid, 4-[[(2-aMino-3,4-dihydro-4-oxo-6-pteridinyl)Methyl]aMino]-
NSC 14972
4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoic acid | [EINECS(EC#)]
240-718-3 | [Molecular Formula]
C14H12N6O3 | [MDL Number]
MFCD00075823 | [MOL File]
119-24-4.mol | [Molecular Weight]
312.28 |
| Chemical Properties | Back Directory | [Melting point ]
>400℃ | [Boiling point ]
610.0±65.0 °C(Predicted) | [density ]
1.69 | [storage temp. ]
2-8°C | [solubility ]
Aqueous Base (Slightly), DMSO (Slightly) | [form ]
neat | [pka]
4.65±0.10(Predicted) | [color ]
Light Yellow to Brown |
| Hazard Information | Back Directory | [Uses]
Pteroic Acid is a constituent as well as a degradation product of Folid Acid (F680300) formed via anzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutama
te synthetase. | [Definition]
ChEBI: 4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoic acid is a pteroic acid. It is functionally related to a 2-aminopteridin-4-ol. It is a conjugate base of a 2-amino-6-{[(4-carboxyphenyl)amino]methyl}-4-hydroxypteridin-1-ium. It is a conjugate acid of a 4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoate. It is a tautomer of a 4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoic acid and a 4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoic acid. | [General Description]
Folic Acid Impurity D is an impurity of the water-soluble B-vitamin, folic acid. Folic Acid is generally used in the treatment of certain types of anemia.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. | [Enzyme inhibitor]
This metabolite (FWfree-acid = 312.29 g/mol; CAS 119-24-4), also known as 4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoic acid, is a structural component of folates. Pteroic acid is a growth factor for a number of Enterococci. Pteroic acid is a yellow powder that is slightly soluble in aqueous NaOH. The lmax values in 0.1 M NaOH are 255, 275, and 365 nm (e = 26300, 23400, and 8900 M–1cm–1, respectively). Target(s): arylamine N-acetyltransferase; dihydrofolate reductase; dihydrofolate synthetase, weakly inhibited; dihydropteroate synthase; glutamate carboxypeptidase; and xanthine oxidase. | [Purification Methods]
Crystallise it from dilute HCl. Dry it in vacuo. Hygroscopic IRRITANT. [Nair et al. J Org Chem 46 3152 1981, Beilstein 26 III/IV 3942.] |
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