| Identification | Back Directory | [Name]
Mirin | [CAS]
1198097-97-0 | [Synonyms]
CS-2593
(Z)-2-Amino-5-(4-hydroxybenzylidene)thiazol-4(5H)-one
(5Z)-2-Amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone
4(5H)-Thiazolone, 2-amino-5-[(4-hydroxyphenyl)methylene]-, (5Z)- | [Molecular Formula]
C10H8N2O2S | [MDL Number]
MFCD05885480 | [MOL File]
1198097-97-0.mol | [Molecular Weight]
220.25 |
| Chemical Properties | Back Directory | [Boiling point ]
441.6±55.0 °C(Predicted) | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
insoluble in EtOH; insoluble in H2O; ≥9.3 mg/mL in DMSO | [form ]
solid | [pka]
8.70±0.30(Predicted) |
| Hazard Information | Back Directory | [Uses]
Mirin is an MRN-ATM pathway inhibitor blocking 3’ and 5’ exonuclease activity associated with Mre11, inducing G2 cell cycle arrest. | [Biological Activity]
mirin is a potent mrn complex inhibitor. mirin inhibits mre11-associated exonuclease activity, rather than alters dna-binding or mrn complex formation. moreover, mirin prevents mrn-dependent activation of atm in response to dna double-strand breaks, with an ic50 value of 12 μm. the mrn complex acts as a dna damage sensor, responsible for maintaining genome stability during dna replication, promoting homology-dependent dna repair and activating atm. the mrn-atm pathway plays an essential role in sensing and signaling from dna double-strand breaks.1. dupré a, boyer-chatenet l, sattler rm, et al. a forward chemical genetic screen reveals an inhibitor of the mre11-rad50-nbs1 complex. nature chemical biology, 2008, 4(2): 119-125. | [storage]
Store at +4°C |
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