| Identification | Back Directory | [Name]
D-erythro-sphingosine-d7 | [CAS]
1246304-34-6 | [Synonyms]
sphingosine-d7
Sphingosine-d7 (d18:1)
D-erythro-sphingosine-d7
D-erythro-sphingosine-d7
D-ERYTHRO-SPHINGOSINE-D7 ;SPHINGOSINE-D7
(2S,3R,4E)-2-aminooctadec-4-ene-16,16,17,17,18,18,18-d7-1,3-diol | [Molecular Formula]
C18H30D7NO2 | [MDL Number]
MFCD31806645 | [MOL File]
1246304-34-6.mol | [Molecular Weight]
306.535 |
| Hazard Information | Back Directory | [Description]
Sphingosine-d7 (d18:1) is intended for use as an internal standard for the quantification of sphingosine (d18:1) by GC- or LC-MS. Sphingosine (d18:1) is formed primarily from the breakdown of ceramide.1 Sphingosine (d18:1) inhibits protein kinase C and phosphatidic acid phosphohydrolase, whereas it activates phospholipase D and diacylglycerol (DAG) kinase.1 Phosphorylation of sphingosine (d18:1) by sphingosine kinases 1 and 2 (SPHK1, SPHK2) produces sphingosine-1-phosphate, a potent bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.2,3,4 | [References]
1. Hannun, Y.A., Luberto, C., and Argraves, K.M. Enzymes of sphingolipid metabolism: From modular to integrative signaling Biochemistry 40(16),4893-4903(2001).
2. Takuwa, Y., Takuwa, N., and Sugimoto, N. The Edg family G protein-coupled receptors for lysophospholipids: Their signaling properties and biological activities J. Biochem. 131(6),767-771(2002).
3. Ishii, I., Fukushima, N., Ye, X., et al. Lysophospholipid receptors: Signaling and biology Annu. Rev. Biochem. 73,321-354(2004).
4. Kluk, M.J., and Hla, T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors Biochim. Biophys. Acta 1582(1-3),72-80(2002). |
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