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Waltonitone is a pentacyclic triterpenoid compound isolated from waltonione. Some studies shown that Waltonitone is a potential anti-tumor drug which can inhibit the proliferation of lung cancer A549 cells and promote their apoptosis. | [Biological Activity]
Waltonitone is a kind of ursane-type pentacyclic triterpenes that can be extracted from the long-stemmed chinensis, which has antitumor activity. | [in vitro]
waltonitone (10 μM, 25 μM; for 48 hours) results in an increment of sub-G1 population in BEL-7402 cells.
Waltonitone (25 μM; for 48 hours) induces BEL-7402 apoptosis cells.
Waltonitone (25 μM; for 48 hours) can effectively activate caspase-3 in BEL-7402 cells.
| [in vivo]
Waltonitone (iv; 20 mg/kg or 50 mg/kg; once every two days for 16 days) inhibits BEL-7402 tumor growth in male athymic mice (BALB/c nu/nu) in vivo. < br/> |
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| Company Name: |
DC Chemicals
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021-58447131 13564518121 |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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MedChemExpress
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021-58955995 |
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www.medchemexpress.com |
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