| Identification | Back Directory | [Name]
E6446 (dihydrochloride) | [CAS]
1345675-25-3 | [Synonyms]
CS-2089
E6446 HCl
E6446 2HCl
E-6446 DihydrochL
E6446;E 6446;E-6446
E6446 hydrochloride
E6446 (dihydrochloride)
6-(3-(Pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)benzo[d]oxazole dihydrochloride | [Molecular Formula]
C27H36ClN3O3 | [MOL File]
1345675-25-3.mol | [Molecular Weight]
486.05 |
| Hazard Information | Back Directory | [Uses]
E6446 is a synthetic antagonist of nucleic acid-sensing TLRs. , In vitro, low doses of E6446 specifically inhibited the activation of human and mouse TLR9. Tenfold higher concentrations of this compound also inhibited the human TLR8 response to single-stranded RNA. In vivo, therapy with E6446 diminished the activation of TLR9 and prevented the exacerbated cytokine response observed during acute Plasmodium infection. Furthermore, severe signs of ECM, such as limb paralysis, brain vascular leak, and death, were all prevented by oral treatment with E6446. |
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