| Identification | Back Directory | [Name]
5'-O-(4,4-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite | [CAS]
146954-75-8 | [Synonyms]
2'-Fluoro-dU CEP
2’-F-rUPhosphoramidite
2'-F-dU Phosphoramidite
5'-O-DMT-2'-F-dU-3'-CEDPA
5'-DMT-2'-F-rU Phosphoramidite
DMT-2′Fluoro-dU Phosphoramidite
DMT-2'-F-DU AMIDITE 0.25G, AB, SINGLE
DMT-2'-F-dU Amidite 0.25g, 89, Single
2'-Deoxy-2'-fluoro-5'-O-DMT-Uridine Phosphoramidite
5'-O-DMT-2'-Fluoro-2'-deoxyuridine 3'-CE phosphoramidite
2'-Fluoro-5'-O-DMT-2'-deoxyuridine-3'-CE-Phosphoramidite
2'-Deoxy-2'-fluoro-5'-O-DMT-Uridine-3'-CED PhosphoraMidite
3-({[(2-{[BIS(4-METHOXYPHENYL)(PHENYL)METHOXY]METHYL}-5-(2,4-DIOXO-3H-PYRIMIDIN-1-YL)-4-FLUOROOXOLAN
5'-O-(4,4-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-O-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite
Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] | [EINECS(EC#)]
2017-001-1 | [Molecular Formula]
C39H46FN4O8P | [MDL Number]
MFCD11113919 | [MOL File]
146954-75-8.mol | [Molecular Weight]
748.78 |
| Chemical Properties | Back Directory | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [form ]
powder | [pka]
9.39±0.10(Predicted) | [color ]
white to off-white | [InChIKey]
HQHQPAYRJJMYQX-YOKGOYKLNA-N | [SMILES]
N1(C=CC(=O)NC1=O)[C@@H]1O[C@H](COC(C2=CC=CC=C2)(C2C=CC(=CC=2)OC)C2=CC=C(C=C2)OC)[C@@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@H]1F |&1:8,10,36,51,r| |
| Hazard Information | Back Directory | [Uses]
5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidite (DMT-2′Fluoro-dU Phosphoramidite) is a uridine phosphoramidite consisting of a fluorine in the 2' position, and the compound is used in the synthesis of DNA. | [Definition]
DMT-2′Fluoro-dU Phosphoramidite is also known as 2'-F-U CE-Phosphoramidite. 2'-F-RNA oligonucleotides adopt an A-form helix on hybridisation to a target. Whereas a hydroxyl group of RNA is a hydrogen bond donor, fluorine appears to be a weak acceptor. These features of 2'-F-RNA oligonucleotides lead to certain interesting properties. For example, it was demonstrated that oligonucleotides hybridise to a RNA oligonucleotide in the following order of increasing stability: DNA < RNA < 2'-OMe-RNA < 2'-F-RNA |
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