| Identification | Back Directory | [Name]
diphenylpyraline | [CAS]
147-20-6 | [Synonyms]
P-253
Dayfen
Hispril
Hystryl
Mepiben
Belfene
Aids033087
Aids-033087
Nsc61825 (HCl)
132-18-3 (Hcl)
benzhydryl 1-methyl-4-piperidyl ether
Piperidine, 4-(diphenylmethoxy)-1-methyl- | [EINECS(EC#)]
205-686-7 | [Molecular Formula]
C19H23NO | [MDL Number]
MFCD00242657 | [MOL File]
147-20-6.mol | [Molecular Weight]
281.39 |
| Chemical Properties | Back Directory | [Boiling point ]
424.06°C (rough estimate) | [density ]
1.0423 (rough estimate) | [refractive index ]
1.5000 (estimate) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Originator]
Diafen,Riker,US,1955 | [Uses]
Diphenylpyraline is an H1 receptor antagonist (an antihistamine), and is commonly prescribed to treat allergic and vasomotor rhinitis. There is also some research being conducted on diphenylpyraline derivatives to determine their antimycobacterial and antifungal activity. | [Definition]
ChEBI: A member of the class of piperidines that is the benzhydryl ether derivative of 1-methyl-4-hydroxypiperidine. A sedating antihistamine, it is used as the hydrochloride for the symptomatic relief of allergic conditions including rhinitis and hay fever, and
in pruritic skin disorders. It is also used as the teoclate salt (piprinhydrinate) as an ingredient in compound preparations for the symptomatic relief of coughs and the common cold. | [Manufacturing Process]
A mixture of 46 grams of 1-methyl-4-piperidinol (0.4 mol), 49.4 grams of
benzhydryl
omide (0.2 mol) and 100 ml of xylene was refluxed for
approximately 24 hours. The reaction mixture separated into two phases with
the upper phase containing the desired ether compound dissolved in xylene.
The lower phase consisted of the hydro
omide salt of the excess 1-methyl-4-
piperidinol. The upper phase was separated from the lower phase and the
desired benzhydryl ether recovered in the crude state by distilling off the
xylene under reduced pressure.
The crude benzhydryl ether was a clear reddish oil. It was dissolved in 75 ml
of 20% hydrochloric acid and the aqueous acid solution then washed three
times with 50 ml portions each of ethyl ether. The aqueous acid solution was
then decolorized with activated carbon and thereafter slowly admixed with 75
ml of 28% aqueous ammonia. The benzhydryl ether separated as an oily
material and was removed from the aqueous mixture by extraction with three
50 ml portions of ethyl ether.
On evaporation of the ethyl ether from the ethyl ether solution, the
benzhydryl ether was recovered as a pale yellow oil. The benzhydryl ether was
dissolved in 60 ml of isopropanol and the isopropanol solution acidified to a
pH of 3 with dry hydrogen chloride-methanol solution. The acidic propanol
solution was then diluted with ethyl ether until a faint turbidity was observed.
In a short time, the crystalline hydrochloride salt of the benzhydryl ether
separated from the propanol solution. The crystallized salt was recrystallized
once from 75 ml of isopropanol with the aid of ethyl ether in order to further
purify the material. A yield of the pure hydrochloride salt of 1-methylpiperidyl-
4-benzhydryl ether of 24.5 grams was obtained. This was 39% of the
theoretical yield. The pure material had a melting point of 206°C. | [Therapeutic Function]
Antihistaminic |
|
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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ChemeGen 中国
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18818260767 |
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https://www.chemegen.com |
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