Hazard Information | Back Directory | [Biological Activity]
Tyrphostin AG1433 (SU1433) is a tyrosine kinase inhibitor. It is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50 of 5.0 μM and 9.3 μM, respectively. It prevents blood vessel formation. | [in vivo]
Chorion allantoic membrane (CAM) assays are used to determine the effects of the Flk-i inhibitors on angiogenesis. Tyrphostin AG1433 (SU1433) is prepared in methylcellulose pellets and applies to the CAMs of 4-6-day- old chicken embryos. Tyrphostin AG1433 prevents the formation of new yessels under the pellets. | [target]
Flk-1 < span> 9.3 μM (IC 50 ) | PDGFRβ 5 μM (IC 50 ) | | [storage]
Store at -20°C |
|
Company Name: |
DC Chemicals
|
Tel: |
021-58447131 13564518121 |
Website: |
https://www.chemicalbook.com/ShowSupplierProductsList927327/0.htm |
|