| Identification | Back Directory | [Name]
AC-YVAD-CMK | [CAS]
178603-78-6 | [Synonyms]
AC-YVAD-CMK
ICE INHIBITOR II
CASPASE-1 INHIBITOR II
AC-TYR-VAL-ALA-ASP-CMK
AC-TYR-VAL-ALA-ASP-CH2CL
N-Ac-Tyr-Val-Ala-Asp-CMK
AC-YVAD-CHLOROMETHYLKETONE
AC-TYR-ALA-ASP-CHLOROMETHYLKETONE
CASPASE 1 INHIBITOR II;AC-YVAD-CMK
AC-TYR-VAL-ALA-ASP-CMK ; AC-YVKD-CMK
AC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE
IL-1BETA CONVERTING ENZYME INHIBITOR II
CASPASE-1 INHIBITOR (CHLOROMETHYLKETONE)
N-ACETYL-TYR-VAL-ALA-ASP CHLOROMETHYL KE
N-ACETYL-TYR-VAL-ALA-ASP CHLOROMETHYL KETONE
IL-1BETA CONVERTING ENZYME (ICE) INHIBITOR II
INTERLEUKIN-1BETA CONVERTING ENZYME INHIBITOR II
interleukin-1B (1L-1B) converting*enzyme (ice) in
Caspase-1 Inhibitor II - CAS 178603-78-6 - Calbiochem
interleukin-1β (il-1β) converting enzyme (ice) inhibitor ii
(ACETYL-L-TYROSYL-L-VALYL-L-ALANYL-L-ASPART-1-YL)CHLOROMETHANE
INTERLEUKIN-1BETA (IL-1BETA) CONVERTING ENZYME (ICE) INHIBITOR II
N-ACETYL-L-TYROSYL-L-VALYL-N-[(1S)-1-(CARBOXYMETHYL)-3-CHLORO-2-OXOPROPYL]-L-ALANINAMIDE
L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-
(4S,7S,10S,13S)-13-(2-Chloroacetyl)-4-(4-hydroxybenzyl)-7-isopropyl-10-methyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid | [Molecular Formula]
C24H33ClN4O8 | [MDL Number]
MFCD00237124 | [MOL File]
178603-78-6.mol | [Molecular Weight]
540.99 |
| Chemical Properties | Back Directory | [Melting point ]
>205°C (dec.) | [RTECS ]
AY3079566 | [storage temp. ]
-20°C | [solubility ]
DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated) | [form ]
White solid | [color ]
white to off-white | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
Ac-YVAD-cmk has been used:
- as an inflammasome inhibitor to add to THP-1 cells or PBMC (peripheral blood mononuclear cell) before stimulation
- as a caspase-1 inhibitor injected to C57BL/6 mice
- as a caspase-1 inhibitor, administered into mice before and during hematopoietic stem cell transplantation (HSCT) to evaluate its effect on bone marrow inflammatory injury
- to abolish the histidine-rich protein II (HRPII) effect on transendothelial electrical resistance (TEER)
- as caspase 1 inhibitor, to treat MCF-7 tumor xenograft mice, to validate the role of inflammasomes activation in tumor growth?in vivo?condition
| [Uses]
Ac-YVAD-CMK is a selective, irreversible inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1). Ac-YVAD-CMK is neuroprotective in a rat model of cerebral ischemia.[Cayman Chemical] | [General Description]
Interleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. Caspase-1 inhibitor II is a cell-permeable, irreversible inhibitor of Caspase-1, Caspase-4, and Caspase-5. Inhibits CPP32/Apopain at a much higher concentration. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation. | [Biochem/physiol Actions]
Ac-YVAD-cmk is a selective ireversible inhibitor of caspase-1 (interleukin-1β converting enzyme, ICE) with some activity also against caspase-4. Ac-YVAD-cmk is anti-apoptotic and has anti-inflammatory and neuroprotective effects, thought to result from its preventing caspase-1 activation of the proinflammatory cytokine, Interleukin-1β. | [storage]
Store at -20°C |
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