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17974-66-2

17974-66-2 Structure

17974-66-2 Structure
IdentificationBack Directory
[Name]

(6R)-6-[(3R,5S,7R,10S,13R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methylheptanoic acid
[CAS]

17974-66-2
[Synonyms]

-DihydroxycoprostanicAcid
3α,7α-Dihydroxycoprostanic Acid
3a,7a-Dihydroxycoprostanic acid
3α,7α-Dihydroxy-5β-cholest-26-oic acid
3α,7α-Dihydroxy-5β-cholestan-26-oic acid
(25RS)-3α,7α-dihydroxy-5β-cholestan-26-oic acid
(6R)-6-[(3R,5S,7R,10S,13R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methylheptanoic acid
[Molecular Formula]

C27H46O4
[MOL File]

17974-66-2.mol
Chemical PropertiesBack Directory
[solubility ]

Chloroform (Slightly), Methanol (Slightly)
[form ]

Solid
[color ]

White to Off-White
Hazard InformationBack Directory
[Uses]

3a,7a-Dihydroxycoprostanic Acid is a precursor of Cholic Acid (C432600), it undergoes side chain oxidation during the synthesis of bile acids. It was found that Zellweger’s syndrome patients have abnormal mitochondrial structure, the organelle that is responsible for the side chain oxidation, and as a consequence, excess amounts of 3a,7a-Dihydroxycoprostanic Acid.
[Definition]

ChEBI: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-oic acid is a cholestanoid that is 5beta-cholestan-26-oic acid substituted by alpha-hydroxy groups at positions 3 and 7 respectively. It has a role as a human metabolite and a mouse metabolite. It is a dihydroxy monocarboxylic acid, a 7alpha-hydroxy steroid, a 3alpha-hydroxy steroid and a cholestanoid. It derives from a hydride of a 5beta-cholestane.
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