| Identification | Back Directory | [Name]
- | [CAS]
1841134-72-2 | [Synonyms]
exo BCN-PEG3-NH2
BCN-exo-PEG3-NH2
exo BCN-PEG3-amine
BCN-PEG3-AMINE (EXO) | [Molecular Formula]
C19H32N2O5 | [MDL Number]
MFCD34470096 | [MOL File]
1841134-72-2.mol | [Molecular Weight]
368.47 |
| Hazard Information | Back Directory | [Biological Activity]
BCN-?exo-?PEG3-?NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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