| Identification | Back Directory | [Name]
Trifluoromethanesulfonic acid difluoromethyl ester | [CAS]
1885-46-7 | [Synonyms]
Difluoromethyl triflate
Difluoromethyl triflate 95%
Difluoromethyl trifluoromethanesulfonate
Difluoromethyl trifluoromethanesulfonate 95%
Trifluoromethanesulfonic acid difluoromethyl ester
Methanesulfonic acid, 1,1,1-trifluoro-, difluoromethyl ester | [Molecular Formula]
C2HF5O3S | [MDL Number]
MFCD28054469 | [MOL File]
1885-46-7.mol | [Molecular Weight]
200.08 |
| Hazard Information | Back Directory | [Uses]
Difluoromethyl triflate (TfO-CHF2) can be used as a reagent:
- In difluoromethylation reaction.
- To prepare difluoromethoxylated heterocycles by reacting with hydroxylated N-based heterocycles.
- To synthesize trifluoromethylated arenes by treating with diaryliodonium salts in the presence of copper and tetrabutylammonium difluorotriphenylsilicate (TBAT).
It allows for a simple method toward the preparation of difluoromethyl ethers and thioethers under basic conditions from alcohols and thiols. Difluoromethyl phenols can also be obtained in a single pot from boronic acids and C-H activation of arenes. | [General Description]
Difluoromethyl triflate (HCF2OTf) is an easy to handle, air-stable and non-ozone-depleting liquid reagent for difluoromethylation. It can be prepared by reacting trifluoromethyltrimethylsilane (TMSCF3) and triflic acid in the presence of titanium tetrachloride (TiCl4). |
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Sigma-Aldrich
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