| Identification | Back Directory | [Name]
3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE | [CAS]
19881-70-0 | [Synonyms]
104523
Windorphen
SALOR-INT L161004-1EA
Windorphen >=98% (HPLC)
Windorphen - CAS 19881-70-0 - Calbiochem
3-CHLORO-2,3-DI(4-METHOXYPHENYL)ACRYLALDEHYDE
(Z)-3-chloro-2,3-bis(4-methoxyphenyl)acrolein
3-CHLORO-2,3-BIS(4-METHOXYPHENYL)ACRYLALDEHYDE
(Z)-3-chloro-2,3-bis(4-methoxyphenyl)prop-2-enal
(Z)-3-chloro-2,3-bis(4-Methoxyphenyl)acrylaldehyde
Benzeneacetaldehyde, α-[chloro(4-methoxyphenyl)methylene]-4-methoxy-, (αZ)- | [Molecular Formula]
C17H15ClO3 | [MDL Number]
MFCD26940341 | [MOL File]
19881-70-0.mol | [Molecular Weight]
302.75 |
| Hazard Information | Back Directory | [Uses]
Windorphen is a selective inhibitor of p300 histone acetyltransferase, a coactivator that associates with?β-catenin,?blocking the Wnt signal required for ventral development. | [Biological Activity]
windorphen is a wnt inhibitor that selectively abrogates the wnt signaling for ventral development.wnt protein is a family of signaling proteins that interacts on the wnt/β-catenin pathways during embryotic development, cell proliferation, migration and adult tissue homeostasis.in canonical wnt/β-catenin reporter cell line stf293, windorphen dose-dependently inhibits wnt3a-inducible topflash-luciferase activity (ic50 of 1.5 mm). in human colon adenocarcinomasw480 cells with defective apc gene that constitutively activates wnt signaling, 72 h treatment of windorphen causes a wide spread apoptosis. [1]in zebrafish embryos, windorphen leads to apparent expansion of the dorsal markers (pax2.1) and marker of rhombomeres 3 and 5 at the six-somite stage (krox0). windorphen selectively inhibits wnt signaling in ventral and lateral regions of the 50% epiboly stage embryo (5.3 hpf). in addition, windoprhen treatment rescues the telencephalon/eye phenotype in the mbl mutant zebrafish (i.e. a defective axin1/β-catenin destruction complex causes abnormal activation of wnt signaling and the loss of telencephalon and eyes.) [1] | [References]
1. hao j, ao a, zhou l et al. selective small molecule targeting β-catenin function discovered by invivo chemical genetic screen. cell rep. 2013 sep 12;4(5):898-904. |
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