| Identification | Back Directory | [Name]
MELITTIN | [CAS]
20449-79-0 | [Synonyms]
C11198
forapin
forapine
melitten
MELITTIN
MELLITIN
melittini
melittin(major)
honeybeemelittin
beevenommelittin
melittin(honeybee)
MELITTIN (NATURAL)
MELITTIN USP/EP/BP
BeeVenomCrystalline
BeeVenomLyophilised
melittin(apiscerana)
Melittin, ≥97% (HPLC)
melittin from honey bee venom
GIGAVLKVLTTGLPALISWIKRKRQQ-NH2
GLY-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-THR-THR-GLY-LEU-PRO-ALA-LEU-ILE-SER-TRP-ILE-LYS-ARG-LYS-ARG-GLN-GLN-NH2
H-GLY-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-THR-THR-GLY-LEU-PRO-ALA-LEU-ILE-SER-TRP-ILE-LYS-ARG-LYS-ARG-GLN-GLN-NH2
GLY-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-THR-THR-GLY-LEU-PRO-ALA-LEU-ILE-SER-TRP-ILE-LYS-ARG-LYS-ARG-GLN-GLN-NH2: GIGAVLKVLTTGLPALISWIKRKRQQ-NH2
Gly-L-Ile-Gly-L-Ala-L-Val-L-Leu-L-Lys-L-Val-L-Leu-L-Thr-L-Thr-Gly-L-Leu-L-Pro-L-Ala-L-Leu-L-Ile-L-Ser-L-Trp-L-Ile-L-Lys-L-Arg-L-Lys-L-Arg-L-Gln-L-Gln-NH2
Gly-L-Ile-Gly-L-Ala-L-Val-L-Leu-L-Lys-L-Val-L-Leu-L-Thr-L-Thr-Gly-L-Leu-L-Pro-L-Ala-L-Leu-L-Ile-L-Ser-L-Trp-L-Ile-L-Lys-L-Arg-L-Lys-L-Arg-L-Glu(NH2)-L-Glu(NH2)-NH2 | [EINECS(EC#)]
629-303-1 | [Molecular Formula]
C131H229N39O31 | [MDL Number]
MFCD00076868 | [MOL File]
20449-79-0.mol | [Molecular Weight]
2846.46 |
| Chemical Properties | Back Directory | [alpha ]
D21 -89.52° (c = 0.409) | [density ]
1.39 | [storage temp. ]
2-8°C
| [solubility ]
Soluble to 1 mg/ml in 20% acetonitrile | [form ]
White to faint tan powder. | [Water Solubility ]
Soluble to 1 mg/ml in water | [Sequence]
H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2 | [InChIKey]
VDXZNPDIRNWWCW-JFTDCZMZSA-N |
| Hazard Information | Back Directory | [Uses]
Causes disruption of normal cellular activity and cell lysis. Binds calmodulin in a calcium-dependent manner. Activates phospholipase A2 (PLA2) and inhibits protein kinase C (PKC) by binding to the catalytic domain in a Mg-ATP sensitive manner. Antirheumatic. | [Definition]
ChEBI: A 26-membered polypeptide consisting of Gly, Ile, Gly, Ala, Val, Leu, Lys, Val, Leu, Thr, Thr, Gly, Leu, Pro, Ala, Leu, Ile, Ser, Trp, Ile, Lys, Arg, Lys, Arg, Gln and Gln-NH2 residues joined in sequence. It is the principal active com
onent of bee venom. | [General Description]
Chemical structure: peptide | [Biochem/physiol Actions]
Melittin acts as an anti-coagulating protein by increasing the time of blood clotting in vitro. Melittin inhibits the activity of S100 calcium-binding protein B (S100B) and plays a vital role in Epilepsy treatment. Melittin retard cathepsin S-induced invasion, proliferation and angiogenesis via inhibition of the vascular endothelial growth factor A (VEGF-A) /VEGF receptor 2 (VEGFR-2)/ mitogen-activated protein kinase 1 (MEK1)/ extracellular signal-regulated kinase 1/2 (ERK1/2) pathway in human MHCC97-H cells (liver cancer cells). Melittin has therapeutic application in various inflammatory diseases such as skin inflammation, neuroinflammation, atherosclerosis, arthritis and liver inflammation. Accumulated melittin degrades phospholipid packing in the cell membrane and causes cell lysis and cell death. | [storage]
Store at -20°C |
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