Identification | Back Directory | [Name]
1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- | [CAS]
2138300-40-8 | [Synonyms]
STING agonist-4 1H-Benzimidazole-5-carboxamide, 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]- | [Molecular Formula]
C34H38N12O4 | [MDL Number]
MFCD32197200 | [MOL File]
2138300-40-8.mol | [Molecular Weight]
678.74 |
Chemical Properties | Back Directory | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: slightly soluble | [form ]
A solid | [pka]
11.97±0.43(Predicted) |
Hazard Information | Back Directory | [Biological Activity]
STING agonist-4 is a stimulator of receptor agonists of the interferon gene (STING) with an apparent inhibition constant IC50 of 20 nM, It is a compound containing two symmetrically related aminobenzimidazoles (ABZI ) based compounds. | [in vitro]
STING agonist-4 (Compound 2) (0.3-30 μM; 2 hours) causes phosphorylation of IRF3 and STING that is inhibited by the TBK1 inhibitor BX795 and induces dose-dependent secretion of IFN-β with an EC 50 of 3.1 μM. STING agonist-4 (Compound 2) (0.001 nM-1 μM) inhibits binding of full-length STING to the solid support with an apparent dissociation constant (K d < /sub> ) of approximately 1.6 nM. It (Compound 2) (0-100 μM) is 18-fold more potent than cGAMP (an endogenous STING ligand), with an EC 50 of 53.9 μM. STING agonist-4 (Compound 2) (3 μM; 4 hours) promotes production of interferon γ-induced protein 10 (IP-10), IL-6 and TNF-α by a mechanism that is dependent on STING-mediated activation of TBK1. Cell Viability Assay Cell Line: | Human peripheral blood mononucl ear cells (PBMCs) | Concentration: | 0.3 μM, 1 μM, 3 μM, 10 μM and 30 μM | Incubation Time: | 2 hours | < td class="col1"> Result: Caused phosphorylation of IRF3 and STING and induced secretion of IFN-β. | | [target]
IC50: 20 nM (STING agonist-4) |
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BOC Sciences
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DC Chemicals
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InvivoChem
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