| Identification | Back Directory | [Name]
4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE | [CAS]
216163-53-0 | [Synonyms]
PD 174265
PD 174265 - CAS 216163-53-0 - Calbiochem
N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide
4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE
Propanamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]- | [Molecular Formula]
C17H15BrN4O | [MDL Number]
MFCD02179208 | [MOL File]
216163-53-0.mol | [Molecular Weight]
371.23 |
| Hazard Information | Back Directory | [Description]
PD 174265 is a potent, cell-permeable inhibitor of the tyrosine kinase activity of the epidermal growth factor (EGF) receptor (IC50 = 0.45 nM). It is effective in cells, blocking tyrosine phosphorylation induced by either EGF or heregulin (IC50s = 39 and 220 nM, respectively). The action of PD 174265 is reversible, which makes it a useful tool for comparative studies with irreversible inhibitors of EGFR kinase activity. | [Uses]
PD 174265 is a potent, cell-permeable, reversible, and selective inhibitor of EGFR tyrosine kinase activity. | [General Description]
A potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 450 pM). The reversible nature of this compound makes it a less effective antitumor agent than PD 168393 (Cat. No. 513033). | [Biochem/physiol Actions]
Target IC50: 450 pM against EGF receptor (EGFR) tyrosine kinase activity | [Enzyme inhibitor]
This substituted quinazoline (FWfree-base = 371.24 g/mol), also known as 4- [(3-bromophenyl)amino]-6-propionylamidoquinazoline, inhibits epidermal growth factor receptor (EGFR) protein-tyrosine kinase, IC50 = 0.45 nM. PD 174265 selectively targets and irreversibly inactivates the epidermal growth factor receptor tyrosine kinase through specific, covalent modification of a Cys-773. See also PD 168393 |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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BOC Sciences
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https://www.bocsci.com |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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