| Identification | Back Directory | [Name]
HOECHST 34580 | [CAS]
23555-00-2 | [Synonyms]
ProaMine
HOE 34580
HOECHST 34580
2,50-bibenzimidazole, 20-[p-(dimethylamino)phenyl]-5-(4-methyl-1-piperazinyl)-
Benzenamine, N,N-dimethyl-4-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]- | [Molecular Formula]
C27H29N7 | [MDL Number]
MFCD03457087 | [MOL File]
23555-00-2.mol | [Molecular Weight]
451.57 |
| Chemical Properties | Back Directory | [Melting point ]
>300℃ | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
Soluble in dimethyl sulfoxide, water | [form ]
powder | [pka]
10.97±0.10, most acidic, temperature:
25 °C; 7.66 ± 0.42, most basic(at 25℃) | [color ]
Yellow to green | [λmax]
392nm | [Biological Applications]
Detecting malaria infected red blood cells,polynucleotides; nucleic acid amplification; nucleic acid sequencing |
| Hazard Information | Back Directory | [Biological Activity]
Hoechst 34580 (HOE 34580) is a cell-permeable blue fluorescent dye used to stain DNA and cell nuclei. It is also a good candidate for the treatment of Alzheimer's disease by inhibiting the formation of amyloid beta (Aβ) with an IC50 value of 0.86 μM. | [in vitro]
Hoechst 34580 prefers to locate near hydrophobic regions with binding affinity with the inhibition constant IC 50 of 0.86±0.05 μM for Hoechst 34580. It is a good candidate for treating the Alzheimer's disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose- dependent manner. And the half-maximal concentration (IC 50 ) is examined. The IC 50 is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86 ±0.05 μM for Hoechst 34580. | [target]
| Target | Value | Aβ
(Cell-free assay) | 0.86 μM |
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| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
http://cn.twochem.com |
|