| Identification | Back Directory | [Name]
3-Keto-N-aminoethyl-Naminocaproyldihydrocinnamoyl Cyclopamine | [CAS]
306387-90-6 | [Synonyms]
3-Keto-N-aMinoethyl-N'-aMinocaproyldihydrocinnaMoyl CyclopaMine, >80% | [Molecular Formula]
C44H63N3O4 | [MDL Number]
MFCD03425585 | [MOL File]
306387-90-6.mol | [Molecular Weight]
697.999 |
| Chemical Properties | Back Directory | [Appearance]
Pale Yellow Solid | [Boiling point ]
875.6±65.0 °C(Predicted) | [density ]
1.15±0.1 g/cm3(Predicted) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under Inert Atmosphere | [solubility ]
Chloroform: Slightly soluble; Methanol: Slightly soluble | [form ]
A solid | [pka]
16.10±0.46(Predicted) | [CAS DataBase Reference]
306387-90-6 |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Solid | [Uses]
Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects ofoncogenic mutations in Smoothened and Patched.1 The KAAD derivative has shown 10-20 fold higher potency than cyclopamine in inhibition of ?-Galactosidase expression i | [Uses]
Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects ofoncogenic mutations in Smoothened and Patched.1 The KAAD-Cyclopamine has shown 10-20 fold higher potency than cyclopamine in inhibition of ?-Galactosidase expression in p2Ptch-1- cells, with similar or lower toxicity.
KAAD-Cyclopamine compound is unstable in solution.
| [storage]
Store at -20°C |
|
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Energy Chemical
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Carbosynth
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Creative Enzymes
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