| Identification | Back Directory | [Name]
OROTIDINE | [CAS]
314-50-1 | [Synonyms]
OROTIDINE
Orotidine ,98%
6-Carboxyuridine
URIDIN-6-CARBOXYLIC ACID
URIDINE-6-CARBOXYLIC ACID
orotidine free acid approx. 90%
Orotidine (Uridine-6-carboxylic acid)
1,2,3,6-Tetrahydro-2,6-dioxo-3-β-D-ribofuranosyl-4-pyrimidinecarboxylic acid
4-Pyrimidinecarboxylicacid, 1,2,3,6-tetrahydro-2,6-dioxo-3-b-D-ribofuranosyl-
4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-3-β-D-ribofuranosyl-
3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,6-dioxopyrimidine-4-carboxylic acid
3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]-2,6-diketo-pyrimidine-4-carboxylic acid | [Molecular Formula]
C10H12N2O8 | [MDL Number]
MFCD00057418 | [MOL File]
314-50-1.mol | [Molecular Weight]
288.21 |
| Chemical Properties | Back Directory | [Melting point ]
>400 °C | [density ]
1.847±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
Solid | [pka]
2.62±0.20(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
Orotidine is a metabolite of Orotic Acid (O691500); a compound used in the preparation of therapeutic agents for chronic obstructive pulmonary disease (COPD) treatment. | [Definition]
ChEBI: A nucleoside formed by attaching orotic acid to a ribose ring via a beta1N(1)-glycosidic bond. | [Enzyme inhibitor]
This water-soluble ribonucleoside (FWfree-acid = 288.21 g/mol; CAS 314-50- 1; lmax of 267 nm in 0.1 N HCl (e = 9570 cm–1M–1; another report lists 9800) and 265 nm in 0.1 N methanolic NaOH (e = 8960 cm–1M–1; another report lists 7800)), first observed in Neurospora crassa, is also foound in the urine of cancer patients treated with 6-azauridine, Orotidine is most likely formed from OMP, its 5’-monophosphate ester and the direct precursor of UMP. Orotidine is readily hydrolyzed in dilute mineral acids. Target(s): orotate phosphoribosyltransferase; orotidine-5’-phosphate decarboxylase. | [storage]
Store at -20°C |
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