| Identification | Back Directory | [Name]
4',5,7-TRIHYDROXYISOFLAVONE-2',6'-D2 | [CAS]
315204-48-9 | [Synonyms]
GeniVida-d2
Bonistein-d2
Genisteol-d2
Baichanin A-d2
GENISTEIN-2',6'-D2
4',5,7-Trihydroxyisoflavone-d2
Genistein-2',6'-d2
See G350010
4',5,7-TRIHYDROXYISOFLAVONE-2',6'-D2
5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d2 | [Molecular Formula]
C15H8D2O5 | [MDL Number]
MFCD04973606 | [MOL File]
315204-48-9.mol | [Molecular Weight]
272.25 |
| Chemical Properties | Back Directory | [Appearance]
Pale Yellow Solid | [Melting point ]
304-305°C dec. | [storage temp. ]
-20°C Freezer | [Stability:]
Light sensitive - Protect from light |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Solid | [Uses]
Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol |
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