| Identification | Back Directory | [Name]
COCHLIOQUINONE A | [CAS]
32450-25-2 | [Synonyms]
Luteoleersin
Cochlioquinone
Coclioquinone A
COCHLIOQUINONE A
(3R)-9-[(1S,2R,3S)-2-Acetyloxy-1,3-dimethylpentyl]-1,2,3,4aβ,5,6,6a,12,12aβ,12b-decahydro-12β-hydroxy-3α-(1-hydroxy-1-methylethyl)-6aα,12bα-dimethylpyrano[3,2-a]xanthene-8,11-dione
Pyrano[3,2-a]xanthene-8,11-dione, 9-[(1S,2R,3S)-2-(acetyloxy)-1,3-dimethylpentyl]-1,2,3,4a,5,6,6a,12,12a,12b-decahydro-12-hydroxy-3-(1-hydroxy-1-methylethyl)-6a,12b-dimethyl-, (3R,4aR,6aR,12S,12aS,12bR)- | [Molecular Formula]
C30H44O8 | [MDL Number]
MFCD08062299 | [MOL File]
32450-25-2.mol | [Molecular Weight]
532.67 |
| Chemical Properties | Back Directory | [Melting point ]
135 °C | [Boiling point ]
638.8±55.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble | [form ]
A yellow lyophilisate | [pka]
11.57±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Cochlioquinone A is an antagonist of CCR5. Diacylglycerol kinase inhibitor. | [Uses]
Cochlioquinone A is the major component of a bioactive pigment isolated from Bipolaris leersia. Cochlioquinone A has recently been shown to be an antagonist of the human chemokine receptor, CCR5, in HIV-1,). Cochlioquinone A is anti-angiogenic and exhibits inhibitory activity against diacylglycerol acyltransferase and NADH-ubiquinone reductase. | [Uses]
Cochlioquinone A, a bioactive compound isolated from D. sacchari and Bipolaris sp., is an inhibitor of diacylglycerol kinase (DGK; Ki = 3.1 μM) and diacylglycerol acyltransferase (DGAT; IC50 = 5.6 μM). It has been shown to reduce the concentration of phosphatidic acid in T cell lymphoma with an IC50 value of 3 μM. It is also reported to compete with macrophage inflammatory protein-1α for binding to human CCR5 chemokine receptors with an IC50 value of 11 μM.[Cayman Chemical] | [Definition]
ChEBI:Cochlioquinone A is a member of oxanes. | [storage]
Store at -20°C |
|
| Company Name: |
Lynnchem
|
| Tel: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
| Company Name: |
Novachemistry
|
| Tel: |
44-20819178-90 02081917890 |
| Website: |
https://www.novachemistry.com/ |
| Company Name: |
MOLEKULA Ltd.
|
| Tel: |
+44 (0) 1747 831066 |
| Website: |
www.molekula.co.uk |
| Company Name: |
AXXORA, LLC
|
| Tel: |
+41 (0) 61 926 8989 |
| Website: |
www.axxora.com |
|