| Identification | Back Directory | [Name]
17β-Hydroxy-5α-androstane-3,11-dione | [CAS]
32694-37-4 | [Synonyms]
11-KDHT
11-Ketodihydrotestosterone
5α-dihydro-11-keto Testosterone
17β-Hydroxy-5α-androstane-3,11-dione
5.alpha.-dihydro-11-keto Testosterone
5alpha-Androstane-3,11-dione-17beta-ol
17beta-Hydroxy-5alpha-androstane-3,11-dione
Androstane-3,11-dione, 17-hydroxy-, (5α,17β)- | [Molecular Formula]
C19H28O3 | [MDL Number]
MFCD00198484 | [MOL File]
32694-37-4.mol | [Molecular Weight]
304.43 |
| Chemical Properties | Back Directory | [Boiling point ]
453.4±45.0 °C(Predicted) | [density ]
1.152±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
crystalline solid | [pka]
14.82±0.60(Predicted) |
| Hazard Information | Back Directory | [Description]
5α-dihydro-11-keto Testosterone is an analytical reference standard that is structurally classified as a steroid hormone. It is a metabolite of 11β-hydroxyandrostenedione and 11β-hydroxytestosterone that has been shown to act as a full androgen receptor agonist with equal potency as that of dihydrotestosterone . The androgenic activity of 5α-dihydro-11-keto testosterone has been implicated in contributing to the androgen pool that drives castration-resistant prostate cancer cells. This product is intended for forensic and research applications. | [Uses]
11-Ketodihydrotestosterone is a naturally occurring steroid and androgen prohormone that is produced primarily, if not exclusively, in the adrenal glands. | [storage]
Store at -20°C | [References]
[1]. bloem lm, storbeck kh, schloms l, et al. 11β-hydroxyandrostenedione returns to the steroid arena: biosynthesis, metabolism and function. molecules. 2013 oct 25;18(11):13228-44.
[2]. swart ac, storbeck kh. 11β-hydroxyandrostenedione: downstream metabolism by 11βhsd, 17βhsd and srd5a produces novel substrates in familiar pathways. mol cell endocrinol. 2015 jun 15;408:114-23.
[3]. storbeck kh, bloem lm, africander d, et al. 11β-hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel c19 steroids with androgenic activity: a putative role in castration resistant prostate cancer mol cell endocrinol. 2013 sep 5;377(1-2):135-46. |
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