| Identification | Back Directory | [Name]
L-Tyr-NCA | [CAS]
3415-08-5 | [Synonyms]
H-TYR-NCA
L-Try-NCA
L-Tyr-NCA
Tyrosine, NCA
L-Tyrosine NCA
34L-Tyr-NCA15-08-5
L-TYR-NCA(3415-08-5)
L-Tyrosine N-carboxyanhydride
N-Carboxy-L-tyrosine anhydride
N-Carbonyl-L-Tyrosine Anhydride
(S)-4-(4-Hydroxybenzyl)oxazolidine-2,5-dione
(4S)-4-[(4-Hydroxyphenyl)methyl]-2,5-oxazolidinedione
(2,5-Oxazolidinedione,4-[(4-hydroxyphenyl)Methyl]-, (4S)- | [Molecular Formula]
C10H9NO4 | [MDL Number]
MFCD11046653 | [MOL File]
3415-08-5.mol | [Molecular Weight]
207.18 |
| Chemical Properties | Back Directory | [Melting point ]
>168°C (dec.) | [density ]
1.423 | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
9.14±0.40(Predicted) | [color ]
Light Beige to Pale Orange | [InChI]
InChI=1S/C10H9NO4/c12-7-3-1-6(2-4-7)5-8-9(13)15-10(14)11-8/h1-4,8,12H,5H2,(H,11,14)/t8-/m0/s1 | [InChIKey]
HOEAPYNDVBABMC-QMMMGPOBSA-N | [SMILES]
O1C(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O |
| Hazard Information | Back Directory | [Uses]
L-Tyr-NCA is used as a reactant in the synthesis of peptides. Peptides such as glutamine penefit in optimum protein utilization for post-injury conditions.
| [Uses]
N-Carbonyl-L-tyrosine Anhydride is used as a reactant in the synthesis of peptides. Peptides such as glutamine penefit in optimum protein utilization for post-injury conditions. | [Synthesis]
L-tyrosine (1.0 g, 6.1 mmol, 1 equiv) was added to a thick-walled pressure bottle, and then 15 mL of analytically pure tetrahydrofuran, propylene oxide (4.3 mL, 61 mmol, 10 equiv), and triphosgene (897 mL) were added. Stir at room temperature for 7 hours. The result solution was Washed, dried, and crystallized. After that, the final product L-tyrosine nitrogen-carboxyl anhydride (L-Tyr-NCA) was obtained.
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