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370-14-9

370-14-9 Structure

370-14-9 Structure
IdentificationBack Directory
[Name]

P-HYDROXYMETHAMPHETAMINE
[CAS]

370-14-9
[Synonyms]

epifen
varitol
Veritol
veritain
prometin
pulsotyl
foledrin
knollh75
pholetone
isodrinum
stimatone
pressitan
promethin
syncordan
terapinyl
PHOLDERIN
paredrinol
pholedrine
sympropamin
rac Pholedrine
n-methylparedrine
P-HYDROXYMETHAMPHETAMINE
d-p-Hydroxymethamphetamine
p-hydroxy-n-methylbenzedrine
p-(2-methylaminopropyl)phenol
4-(2-methylaminopropyl)phenol
4-Hydroxy-N-methylamphetamine
p-(2-(methylamino)propyl)-pheno
Phenol, 4-[2-(methylamino)propyl]-
1-(p-oxyphenyl)-2-methylaminopropan
4-[(S)-2-(Methylamino)propyl]phenol
beta(p-oxy-phenyl)isopropylmethylamin
1-(p-hydroxyphenyl)-2-methylaminopropane
p-hydroxy-n,alpha-dimethyl-phenethylamin
p-hydroxy-n,alpha-dimethylphenethylamine
beta-(p-hydroxyphenyl)isopropylmethylamine
alpha-(p-oxyphenyl)-beta-methylaminopropane
(S)-N,α-Dimethyl-4-hydroxybenzeneethanamine
(αS)-4-Hydroxy-N,α-dimethylbenzeneethanamine
alpha-(p-hydroxyphenyl)-beta-methylaminopropane
[EINECS(EC#)]

206-725-0
[Molecular Formula]

C10H15NO
[MDL Number]

MFCD00178702
[MOL File]

370-14-9.mol
[Molecular Weight]

165.23
Chemical PropertiesBack Directory
[Melting point ]

162-163°
[Boiling point ]

293.09°C (rough estimate)
[density ]

1.0203 (rough estimate)
[refractive index ]

1.4820 (estimate)
[storage temp. ]

−20°C
[form ]

neat
[pka]

9.82±0.15(Predicted)
Safety DataBack Directory
[Hazard Codes ]

Xi,T,F
[Risk Statements ]

36/37/38-39/23/24/25-23/24/25-11
[Safety Statements ]

26-36-45-36/37-16-7
[WGK Germany ]

3
[RTECS ]

SL8400000
[Toxicity]

LD50 parenteral in mouse: 100mg/kg
Hazard InformationBack Directory
[Chemical Properties]

Off-White Solid
[Originator]

Pholedrine Sulfate, ZYF Pharm Chemical
[Definition]

ChEBI: Pholedrine is a member of amphetamines.
[Manufacturing Process]

100 g β-(methoxyphenyl)isopropylamine prepared, for example by reduction of p-methoxybenzylmethylketone with hydrogen and nickel catalyst in presence of ammonia or by Mannix's method, 250 ml ethanol and calculated quantity of solution of formaldehyde and 70 g activated aluminum shaving were heated for 6 hours by stirring. The mixture was filtered, the solvent was removed in vacuum and the residue was dissolved in ethanol contained hydrochloric acid. The prepared hydrochloride of β-(pmethoxyphenyl)isopropylmethylamine had MP: 174°C.
In practice it is usually used as sulfate.
[Therapeutic Function]

Sympathomimetic, Mydriatic, Analeptic, Vasopressor
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