| Identification | Back Directory | [Name]
CIRAZOLINE HYDROCHLORIDE | [CAS]
40600-13-3 | [Synonyms]
LD-3098
Cirazoline hydrochlo
LD 3098 hydrochloride
CIRAZOLINE HYDROCHLORIDE
CIRAZOLINE HYDROCHLORIDE SELECTIVE A1 AD RENOCE
2-(2-CYCLOPROPYLPHENOXYMETHYL)IMIDAZOLINE HYDROCHLORIDE
2-[(2-cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazolium chloride
2-[(2-CYCLOPROPYLPHENOXY)METHYL]-4,5-DIHYDRO-1H-IMIDAZOLE HYDROCHLORIDE | [EINECS(EC#)]
254-995-3 | [Molecular Formula]
C13H17ClN2O | [MDL Number]
MFCD00274034 | [MOL File]
40600-13-3.mol | [Molecular Weight]
252.74 |
| Hazard Information | Back Directory | [Description]
Cirazoline is an α1-adrenergic receptor (α1-AR) agonist (Kis = 120, 960, and 660 nM for recombinant α1A-, α1B-, and α1D-ARs, respectively, in CHO cell membranes). It acts as a full agonist at α1A- and a partial agonist at α1B- and α1D-ARs in vitro (EC50s = 70.7, 79.4, and 239.8 nM, respectively). It also acts as an antagonist at α2-ARs with a pA2 value of 7.56 to inhibit the norepinephrine-induced twitch response in isolated pig ileum. Cirazoline (0.01-1 μg/kg) decreases blood pressure when administered via microinjection to the nucleus reticularis lateralis (NRL) of anesthetized normotensive cats. It enhances spatial memory and reduces depressive- and anxiety-like behavior in mice when administered at a concentration of 10 mg/L in drinking water for 2-9 months. It also enhances performance in the variable delayed response task in aged rhesus monkeys at high doses of 1-10 μg/kg but impairs performance at lower doses of 0.01-1 μg/kg. | [Uses]
Cirazoline hydrochloride has been used to activate the α1-noradrenergic receptors and to study the inhibitory effect of neurokinin1 (NK1) antagonists on respiratory activity using the brainstem transverse slice. | [Biological Activity]
Selective α 1 agonist. Also available as part of the α 1 -Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™ . | [Biochem/physiol Actions]
Cirazoline is a selective α1-adrenoceptor agonist and also a non-selective ligand for the imidazoline binding site. Cirazoline dereases spatial working memory performance in aged monkeys. | [storage]
Store at RT |
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Sigma-Aldrich
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