| Identification | Back Directory | [Name]
YDL223C | [CAS]
489408-02-8 | [Synonyms]
YDL223C
1H-Pyrazole-1-acetamide, N-[3-(aminocarbonyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]-5-methyl-3-(trifluoromethyl)- | [EINECS(EC#)]
206-141-6 | [Molecular Formula]
C16H17F3N4O2S | [MDL Number]
MFCD02053612 | [MOL File]
489408-02-8.mol | [Molecular Weight]
386.39 |
| Hazard Information | Back Directory | [Description]
Shmoo tip protein, substrate of Hub1p ubiquitin-like protein; mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis; HBT1 has a paralog, YNL195C, that arose from the whole genome duplication. | [Biochem/physiol Actions]
HBT1(YDL223C) is an AMPA-R [alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor] potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate dependent manner. |
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