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5653-80-5

5653-80-5 Structure

5653-80-5 Structure
IdentificationBack Directory
[Name]

S(+)-METHADONE HYDROCHLORIDE INACTIVE EN ANTIOMER O
[CAS]

5653-80-5
[Synonyms]

d-methadone
6s-methadone
dextromethadone
l-(+)-methadone
S-(+)-Methadone
4-diphenyl-6-(dimethylamino)-(s)-3-heptanon
d-6-(dimethylamino)-4,4-diphenyl-3-heptanone
(s)-6-(dimethylamino)-4,4-diphenyl-3-heptanone
(6S)-6-(diMethylaMino)-4,4-diphenylheptan-3-one
S(+)-METHADONE HYDROCHLORIDE INACTIVE EN ANTIOMER O
3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, (6S)-
[Molecular Formula]

C21H27NO
[MDL Number]

MFCD00151717
[MOL File]

5653-80-5.mol
[Molecular Weight]

309.45
Chemical PropertiesBack Directory
[Melting point ]

100.5°C
[Boiling point ]

449.71°C (rough estimate)
[density ]

1.0350 (rough estimate)
[refractive index ]

1.5614 (estimate)
[solubility ]

H2O: soluble
[form ]

solid
[pka]

9.05±0.50(Predicted)
[color ]

white
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

22-36/37/38-42/43
[Safety Statements ]

22-26-36/37/39-45
[RIDADR ]

UN 2811 6.1/PG 3
[WGK Germany ]

3
[RTECS ]

MJ6000000
[Toxicity]

LD50 oral in mouse: 252mg/kg
Hazard InformationBack Directory
[Uses]

Dextromethadone-D3 is an impurity of Dextromethadone (CAS #: 5653-80-5). Dextromethadone is used in therapy for treating or preventing depression or other mood diseases.
[Definition]

ChEBI:Dextromethadone is a 6-(dimethylamino)-4,4-diphenylheptan-3-one that has (S)-configuration. It is the less active enantiomer of methadone and has very little activity on opioid receptors and mainly responsible for the inhibition of hERG K+ channels and thus for cardiac toxicity. The drug is currently under clinical development for the treatment of major depressive disorder. It has a role as a NMDA receptor antagonist and an opioid analgesic. It is an enantiomer of a levomethadone.
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