| Identification | Back Directory | [Name]
2-CHLORO-N-(4-CHLORO-3-DIMETHYLSULFAMOYL-PHENYL)-ACETAMIDE | [CAS]
568544-03-6 | [Synonyms]
GSTO1-IN-1
GSTO1 inhibitor 1
2-CHLORO-N-(4-CHLORO-3-DIMETHYLSULFAMOYL-PHENYL)-ACETAMIDE
Acetamide, 2-chloro-N-[4-chloro-3-[(dimethylamino)sulfonyl]phenyl]- | [Molecular Formula]
C10H12Cl2N2O3S | [MDL Number]
MFCD03965279 | [MOL File]
568544-03-6.mol | [Molecular Weight]
311.18 |
| Hazard Information | Back Directory | [Biological Activity]
GSTO1-IN-1 is a potent glutathione S-transferase omega 1 (GSTO1) inhibitor with IC50 of 31 nM. | [in vitro]
GSTO1-IN-1 (C1-27) potently inhibits GSTO1 enzyme activity with an IC 50 value of 31 nM. GSTO1-IN-1 also potently competes with 5-chloromethylfluorescein diacetate (CMFDA) for binding to recombinant protein, as well as endogenous GSTO1 in the milieu of a soluble proteome. HCT116 cells treated with GSTO1-IN-1 also show a decrease in cell viability in a dose-dependent manner. GSTO1-IN-1 inhibits the clonogenic survival of HCT116 cells at sub-micromolar concentrations. | [target]
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Twochem Co.Ltd.
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InvivoChem
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13549236410 |
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MedChemExpress
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