| Identification | Back Directory | [Name]
DESIPRAMINE HYDROCHLORIDE | [CAS]
58-28-6 | [Synonyms]
ex4355
g35020
jb8181
Petylyl
Nortimil
RMI-9384A
norpramin
pertofran
pertofrane
nsc-114901
DESIPRAMINE HCL
dmihydrochloride
3-(5,6-dihydrobenzo[b][1
DESIPRAMINE HYDROCHLORIDE
Desimipramine-hydrochloride
DESIPRAMINEHYDROCHLORIDE,USP
DesipraMine Monohydrochloride
demethylimipraminehydrochloride
imipraminedemethylhydrochloride
desmethylimipraminehydrochloride
Desipramine hydrochloride solution
Desipramine Hydrochloride (125 mg)
Desipramine solution hydrochloride
DESIPRAMINE HYDROCHLORIDE METHANOL*SOLUT ION
n-(gamma-methylaminopropyl)iminodibenzylhydrochloride
Desipramine Hydrochloride (125 mg)I0E2831.000mg/mg(dr)
10,11-Dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine
10,11-DIHYDRO-N-METHYL-5-H-DIBENZ-[B,F]AZEPINE HYDROCHLORIDE
5-[3-(Methylamino)propyl]-5H-dibenz[b,f]azepine hydrochloride
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methyl-amine
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methyl-propan-1-amine
f)azepine,10,11-dihydro-5-(3-(methylamino)propyl)-5h-dibenz(hydrochlorid
f)azepine,10,11-dihydro-5-(3-(methylamino)propyl)-5h-dibenz(monohydrochlor
10,11-dihydro-5-(3-(methylamino)propyl)-5h-dibenz(b,f)azepinehydrochloride
10-11-Dihydro-N-methyl-5H-dibenz(Z)[b,f]azepine-5-propanaminehydrochloride
5H-Dibenzb,fazepine-5-propanamine, 10,11-dihydro-N-methyl-, monohydrochloride
[3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]methylamine hydrochloride
10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepine monohydrochloride
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine hydrochloride
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methyl-propan-1-amine hydrochloride | [EINECS(EC#)]
200-373-1 | [Molecular Formula]
C18H23ClN2 | [MDL Number]
MFCD00058108 | [MOL File]
58-28-6.mol | [Molecular Weight]
302.84 |
| Chemical Properties | Back Directory | [Appearance]
White To Off-White Solid | [Melting point ]
214-2160C | [Fp ]
11 °C | [storage temp. ]
2-8°C
| [solubility ]
H2O: 50 mg/mL
| [form ]
powder
| [color ]
white to off-white
| [Water Solubility ]
Soluble to 100 mM in water |
| Hazard Information | Back Directory | [Chemical Properties]
White To Off-White Solid | [Uses]
Tricyclic antidepresant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter. | [Uses]
Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter. | [Definition]
ChEBI: The hydrochloride salt of desipramine. | [Biological Activity]
Tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (K i values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively). | [Originator]
Pertofran,Geigy,UK,1963 | [Manufacturing Process]
Oxidative coupling of o-nitrotoluene gives 4,4'-dinitrodibenzyl which is reduced
with hydrogen to the diamine. The diamine is pyrolyzed to give
dihydrobenzazepine. This is reacted with N-(3-chloropropyl)-Nmethylbenzamine to give N-benzyldesipramine. This is debenzylated by
reductive cleavage and then reacted with HCl. | [Brand name]
Norpramin (Sanofi Aventis); Pertofrane (Sanofi Aventis). | [Therapeutic Function]
Psychostimulant | [General Description]
The structure and salient properties of desipramine hydrochloride,10,11-dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine monohydrochloride, 5-(3-methylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride(Norpramin, Pertofrane), are discussed under the heading,Imipramine. Among tricyclics, desipramine would be consideredwhen few anticholinergic effects or a low level of sedationare important. It is a SNERI. | [Biochem/physiol Actions]
Desipramine is used to treat depression. It is also used to manage enuresis in children. Desipramine helps to eliminate the pain triggered by diabetic neuropathy. | [storage]
Desiccate at +4°C |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,T,F | [Risk Statements ]
22-36/37/38-42/43-48/23/24/25-23/24/25-11-39/23/24/25 | [Safety Statements ]
7-16-36/37-45-26-24-22 | [RIDADR ]
UN 1230 3/PG 2
| [WGK Germany ]
3
| [RTECS ]
HO0525000
| [HS Code ]
2933996100 | [Safety Profile]
Poison by ingestion,
intraperitoneal, subcutaneous, and
intravenous routes. Human systemic effects
by ingestion: decreased urine volume,
sodium level changes, chlorine level
changes. An experimental teratogen. Other
experimental reproductive effects. Mutation
data reported. When heated to
decomposition it emits very toxic fumes of
NO, and HCI. | [Toxicity]
LD50 in mice, rats (mg/kg): 500, 385 orally; 94, 48 i.p.; 420, 183 s.c. (Eriksoo, Rohte) |
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