| Identification | Back Directory | [Name]
LORMETAZEPAM | [CAS]
848-75-9 | [Synonyms]
Loramet
WY-4082
Noctamid
Ergocalm
RO 5-5516
LORMETAZEPAM
lormethazepam
METHYLLORAZEPAM
N-Methyllorazepam
(RS)-Lormetazepam
Lormetazepam solution
LORMETAZEPAM USP/EP/BP
Lormetazepam Solution, 100ppm
LORMETAZEPAM METHANOL SOLUTION
7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-3H-1,4-benzodiazepin-2-one
7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1h-1,4-benzodiaze
2h-1,4-benzodiazepin-2-one,7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy
2h-1,4-benzodiazepin-2-one,1,3-dihydro-7-chloro-5-(o-chlorophenyl)-3-hydroxy-1
7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one
7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
7-Chloro-1,3-dihydro-5-(o-chlorophenyl)-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one
2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(o-chlorophenyl)-3-hydroxy-1-methyl-
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl- (9CI)
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl- (7CI, 8CI) | [EINECS(EC#)]
212-700-5 | [Molecular Formula]
C16H12Cl2N2O2 | [MDL Number]
MFCD00058578 | [MOL File]
848-75-9.mol | [Molecular Weight]
335.18 |
| Chemical Properties | Back Directory | [Melting point ]
163-168°C | [Boiling point ]
575.8±50.0 °C(Predicted) | [density ]
1.4463 (rough estimate) | [refractive index ]
1.6100 (estimate) | [Fp ]
9℃ | [storage temp. ]
Controlled Substance, -20°C Freezer | [pka]
11.60±0.40(Predicted) |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Green Solid | [Originator]
Loramet ,Wyeth, W. Germany,1980 | [Uses]
An analog of Lorazepam (L469850). Sedative, hypnotic.
Controlled substance (depressant). | [Definition]
ChEBI: Lormetazepam is a 1,4-benzodiazepinone compound having a methyl substituent at the 1-position, a hydroxy substituent at the 3-position, a 2-chlorophenyl group at the 5-position and a chloro substituent at the 7-position. It has a role as a sedative. It is a 1,4-benzodiazepinone and an organochlorine compound. | [Manufacturing Process]
To a suspension of 3.4 g of 3-acetoxy-7-chloro-1,3-dihydro-5-(ochlorophenyl)-2H-1,4-benzodiazepin-2-one in 80 ml of alcohol was added 6 ml of 4 N sodium hydroxide. After complete solution had taken place a solid precipitated that redissolved upon the addition of 80 ml of water. The solution was acidified with acetic acid to give white crystals. After recrystallization from alcohol the compound melted at 192°C to 194°C. | [Therapeutic Function]
Hypnotic | [Clinical Use]
#N/A | [Drug interactions]
Potentially hazardous interactions with other drugs
Antibacterials: metabolism possibly increased by
rifampicin.
Antipsychotics: increased sedative effects; risk of
serious adverse effects in combination with clozapine.
Antivirals: concentration possibly increased by
ritonavir.
Disulfiram: metabolism inhibited, increased sedative
effects.
Sodium oxybate: enhanced effect - avoid. | [Metabolism]
Lormetazepam is metabolised in the liver to the inactive
glucuronide, and excreted in the urine. |
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