| Identification | Back Directory | [Name]
amifloxacin | [CAS]
86393-37-5 | [Synonyms]
AMFX
Win-49375
amifloxacin
amifloxacin USP/EP/BP
Inhibitor,Win-49375,Amifloxacin,inhibit,Win 49375,Bacterial
6-Fluoro-1,4-dihydro-1-(methylamino)-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
6-Fluoro-1,4-dihydro-1-(methylamino)-7-(4-methylpiperazin-1-yl)-4-oxo-3-quinolinecarboxylic acid
3-Quinolinecarboxylic acid, 6-fluoro-1,4-dihydro-1-(methylamino)-7-(4-methyl-1-piperazinyl)-4-oxo- | [EINECS(EC#)]
289-231-8 | [Molecular Formula]
C16H19FN4O3 | [MDL Number]
MFCD00864981 | [MOL File]
86393-37-5.mol | [Molecular Weight]
334.349 |
| Chemical Properties | Back Directory | [Melting point ]
300 °C (decomp) | [Boiling point ]
532.5±60.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Store in freezer, under -20°C | [pka]
6.17±0.41(Predicted) |
| Hazard Information | Back Directory | [Uses]
Antibacterial. | [Definition]
ChEBI: Amifloxacin is a member of quinolines. | [Enzyme inhibitor]
This fluoroquinolone-class antibiotic (FW = 334.31 g/mol; CAS 86393-37-
5) is a broad-spectrum systemic agent that targets Type II DNA
topoisomerases (gyrases) required for bacterial replication and transcription
. Ninety percent of Escherichia coli, Klebsiella species, Aeromonas,
Salmonella, Shigella, Citrobacter, Enterobacter species, Proteus mirabilis,
Serratia marcescens, and Morganella morganii were inhibited by ≤ 0.5
μg/mL. Amifloxacin inhibited Branhamella, Haemophilus, and
Neisseria at ≤ 0.25 μg/mL, and 90% of Pseudomonas aeruginosa,
including gentamicin and carbenicillin-resistant isolates, at 4 ≤g/mL. It
also inhibited Staphylococci, including methicillin-resistant isolates, but
was less active against Streptococci and Bacteroides species. For
mechanism of action, see Ciprofloxacin, which is the prototypical member
of this antibiotic class. |
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