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870223-96-4

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870223-96-4 Structure

870223-96-4 Structure
IdentificationBack Directory
[Name]

4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide
[CAS]

870223-96-4
[Synonyms]

AMG-Tie2
AMG-Tie2-1
PubChem22413
4-Methyl-3-((3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)-N-(3-(trifluoromethyl)phenyl)b
4-methyl-3-((3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)-N-(3-(trifluoromethyl)phenyl)benzamide
4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide
Benzamide, 4-methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]-
870223-96-4; AMG-TIE2; AMG-TIE2-1; 4-METHYL-3-(3-(2-(METHYLAMINO)PYRIMIDIN-4-YL)PYRIDIN-2-YLOXY)-N-(3-(TRIFLUOROMETHYL)PHENYL)BENZAMIDE; 4-METHYL-3-[[3-[2-(METHYLAMINO)-4-PYRIMIDINYL]-2-PYRIDINYL]OXY]-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE; PUBCHEM22413
[Molecular Formula]

C25H20F3N5O2
[MDL Number]

MFCD16038641
[MOL File]

870223-96-4.mol
[Molecular Weight]

479.45
Chemical PropertiesBack Directory
[density ]

1.357
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 10mg/mL; DMSO: 10mg/mL; DMSO:PBS (pH 7.2) (1:2): 0.3mg/mL
[form ]

A solid
Hazard InformationBack Directory
[Description]

AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) and VEGF receptor 2 (VEGFR2) with IC50 values of 1 and 3 nM, respectively, in a homogenous time-resolved fluorescence (HTRF) assay. It inhibits angiopoietin 1-induced Tie2 autophosphorylation in EA.hy926 human endothelial cells (IC50 = 10 nM).
[Uses]

AMG-Tie 2-1 is a pyridinyltriazine Tie-2 kinase inhibitor. A useful research chemical for cancer metabolism research studies.
[storage]

Store at -20°C
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