| Identification | Back Directory | [Name]
4'-METHOXY-2-METHYL-BIPHENYL | [CAS]
92495-54-0 | [Synonyms]
AKOS BAR-1281
4-o-Tolylanisole
Anisole, p-(o-tolyl)- (7CI)
4'-METHOXY-2-METHYL-BIPHENYL
4-METHOXY-2'-METHYL-1,1'-BIPHENYL
1-methoxy-4-(2-methylphenyl)benzene | [Molecular Formula]
C14H14O | [MDL Number]
MFCD06802485 | [MOL File]
92495-54-0.mol | [Molecular Weight]
198.26 |
| Questions And Answer | Back Directory | [Synthesis]
Open to the atmosphere, 4-bromoanisole (1.87 g, 10 mmol), o-tolylboronic acid (1.50 g, 11 mmol), KF (spray dried, dried in an oven overnight prior to use, 1.92 g, 33 mmol), and THF (10 mL) were added to a 100-ml round-bottomed Schlenk flflask equipped with a stir bar. The reaction system was flflushed with argon for about 5 min. P(t-Bu)3 (1.9 × 10–4 M stock solution in THF; 2.31 mL, 5.0 × 10–5 mmol) and Pd2(dba)3 (2.16 × 10–5 M stock solution in THF; 2.31 mL, 5.0 × 10–5 mmol) in THF were added sequentially. After 48 h at room temperature, the reaction mixture was diluted with ether or EtOAc, fifiltered through a pad of silica gel with copious washings, and then concentrated. The crude product was then purifified via column chromatography eluting with 5% ether in hexane to yield 1.94 g (98%) of 4-methoxy-2´-methylbiphenyl as a colorless liquid.
|
|
| Company Name: |
AlliChem, LLC
|
| Tel: |
301-317-5072 |
| Website: |
www.allichemllc.com |
|