1135-66-6

中文名称异长叶烯

英文名称 Isolongifolene

CAS 1135-66-6

EINECS 编号 214-494-2

分子式 C15H24

MDL 编号 MFCD00042616

分子量 204.35

MOL 文件 1135-66-6.mol

更新日期 2024/04/25 17:12:34

1135-66-6 结构式

基本信息物理化学性质安全数据应用领域知名试剂公司产品信息常见问题列表

基本信息

中文别名

(2S)-1,3,4,5,6,7-六氢-1,1,5,5-四甲基-2H-2,4A-亚甲基萘
异长叶烯
(-)-异长叶烯

英文别名

(1R)-2,2,7,7-TETRAMETHYLTRICYCLO[6.2.1.0(1.6)]UNDEC-5-ENE
(-)-ISOLONGIFOLENE
ISOLONGIFOLENE
(-)-Isolongifoline
(2s)-1,3,4,5,6,7-hexahydro-1,1,5,5
(2s)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2h-2,4a-methanonaphthalene
2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-
2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S,4aR)-(-)-
2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S-cis)-
3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-4a-methanonaphthalen(2s)-2h-1
4a-Methanonaphthalene,1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-,(2S)-2H-2
Isolongipholene
C15 H24, 2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S)-
ISOLONGIFOLENE(SG)
(2s)-2h-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-4a-methanonaphthalen
1,3,4,5,6,7-Hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene
ISOLONGIFOLENE WITH GC
(2S,4aR)-1,2,3,4,4a,5,6,7-Octahydro-1,1,5,5-tetramethyl-2,4a-methanonaphthalene
(2S,4aR)-1,3,4,5,6,7-Hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene
(2S,4aR)-1,3,4,5,6,7-Hexahydro-1,1,5,5-tetramethyl-2H-2α,4aα-methanonaphthalene

所属类别

香精与香料：萜烯烃

物理化学性质

外观性质微黄色液体，不溶于水，溶于乙醇等有机溶剂。沸点：113～114℃折光率：1.499密度：0.930闪点：49 °C

沸点255-256 °C

密度0.930 g/mL at 20 °C(lit.)

蒸气压5.49Pa at 25℃

折射率n20/D 1.499

闪点49°C

储存条件2-8°C

溶解度DMSO: 10 mg/mL (48.94 mM)

气味 (Odor)at 100.00 %. woody dusty amber incense

香型woody

旋光性 (optical activity)[α]20/D 138±2°, c = 1% in ethanol

水溶解性59.998μg/L at 25℃

BRN2207559

LogP5.77 at 25℃

CAS 数据库1135-66-6(CAS DataBase Reference)

NIST化学物质信息2H-2,4a-methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2s)-(1135-66-6)

EPA化学物质信息2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S,4aR)- (1135-66-6)

安全数据

危险性符号(GHS)

GHS02

警示词警告

危险性描述H225-H301+H311+H331-H370

防范说明P210-P280-P301+P310+P330-P302+P352+P312-P304+P340+P311

危险类别码R10

危险品运输编号UN 2319 3/PG 3

WGK Germany3

危险等级3.2

包装类别III

应用领域

用途一

是制造具有木香香气的合成香料异长叶烷酮和异长叶甲酸酯的主要原料

用途二

可用于合成异长叶烷酮、环氧长叶烯和乙酰基异长叶烷酮等重要香料。

知名试剂公司产品信息

Sigma Aldrich

1135-66-6(sigmaaldrich)

常见问题列表

生物活性

Isolongifolene ((-)-Isolongifolene) 是一种从 Murraya koenigii 中分离的三环倍半萜烯。Isolongifolene 通过调节 P13K/AKT/GSK-3β 信号通路来减轻鱼藤酮诱导的氧化应激，线粒体功能障碍和细胞凋亡。Isolongifolene 具有抗氧化，抗炎，抗癌和神经保护的特性。

体外研究

Isolongifolene (0-50 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment significantly alleviates Rotenone-induced cytotoxicity in SH-SY5Y cells in a dose-dependent manner.
Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone-induced apoptosis in SH-SY5Y cells.
Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Furthermore regulation of p-P13K, p-AKT and p-GSK-3β expression by Isolongifolene.

Cell Viability Assay

Cell Line:	SH-SY5Y neuroblastoma cells
Concentration:	0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM and 50 µM
Incubation Time:	26 hours
Result:	Significantly alleviated Rotenone-induced cytotoxicity in SH-SY5Y cells.

Apoptosis Analysis

Cell Line:	SH-SY5Y neuroblastoma cells
Concentration:	10 µM
Incubation Time:	26 hours
Result:	Attenuated Rotenone-induced apoptosis in SH-SY5Y cells.

Western Blot Analysis

Cell Line:	SH-SY5Y neuroblastoma cells
Concentration:	10 µM
Incubation Time:	26 hours
Result:	Attenuated rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Prevented the rotenone-induced decreased phosphorylation of GSK-3β.