14417-88-0

中文名称 CS-2397

英文名称 Melinamide

CAS 14417-88-0

分子式 C26H41NO

分子量 383.61

MOL 文件 14417-88-0.mol

14417-88-0 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

甲亚油酰胺
化合物 T16036

英文别名

AC 223
CS-2397
Melinamide
DL-a-Methylbenzyl linoleamide
N-(a-Methylbenzyl)linoleamide
N-(2-methylbenzyl)linoleamide
N-(α-Methylbenzyl)linoleamide
DL-N-(a-Methylbenzyl)linoleamide
DL-N-(α-Methylbenzyl)linoleamide
DL-N-(α-Methylbenzyl)linoleamide

物理化学性质

熔点<4°

沸点bp0.03 200-215°; bp0.07 200-204°

密度0.928±0.06 g/cm3(Predicted)

折射率nD23 1.5050; nD30 1.4863

储存条件-20°C储存

溶解度溶于二甲基亚砜

酸度系数(pKa)15.56±0.46(Predicted)

CAS 数据库14417-88-0

常见问题列表

生物活性

Melinamide是不饱和长链脂肪酸的酰胺衍生物。它是胆固醇吸收的抑制剂，IC50值为20.9 μM。

靶点

IC50: 20.9 μM (cholesterol)

体外研究

DL-Melinamide inhibits acyl CoA:cholesterol acyltransferase activity (ACAT) in the mucosal microsomes, with 50% inhibition occurring at approximately 0.5 μM. Kinetic studies indicate that DL-Melinamide is an uncompetitive inhibitor of acyl CoA:cholesterol acyltransferase. D-Melinamide is found to be a more effective inhibitor than L-Melinamide.

体内研究

Melinamide is a new hypocholesterolaemic drug. Melinamide causes a substantial decrease of the enhanced intestinal ACAT activity in diabetic rats, but does not affect intestinal cholesterol esterase activity. Furthermore, marked improvement of hypercholesterolaemia in cholesterol-fed diabetic rats occurrs concomitantly with the drug treatment.