1874-54-0
1874-54-0 结构式
基本信息
中文别名
阿洛酮糖腺苷 英文别名
U-9586NSC 53104
psicofuranin
psicofuranine
Angustmycin C
Psicofuranosyladenine
1'-(Hydroxymethyl)adenosine
Psicofuranine [AngustMycin C]
9-beta-D-Psicofuranosyladenine
Adenosine, 1'-C-(hydroxymethyl)-
物理化学性质
熔点212-214℃ (decomposition)
比旋光度D25 -68° (dimethylformamide)
沸点720.1±70.0 °C(Predicted)
密度2.02±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)12.87±0.70(Predicted)
形态固体
颜色白色至灰白色
常见问题列表
生物活性
Psicofuramine 是一种核苷抗生素，具有抑制黄嘌呤 5'-磷酸氨化酶的作用。Psicofuramine 还可以特异性抑制 GMP 合酶，并中断寄生虫的生长。Psicofuramine 对恶性疟原虫的生长具有剂量依赖性抑制作用。靶点
Xanthosine 5'-phosphate aminase
P. falciparum
E. coli
体外研究
Psicofuranine specifically inhibits bacterial GMP synthase as demonstrated by isolation of Psicofuranine-resistant Escherichia coli mutants with mutations in the gene encoding GMP synthase and inhibition of bacterial growth. Psicofuranine exhibits a dose-dependent inhibition of P. falciparum growth with an IC 50 of 0.3 mM. The Psicofuranine inhibitory concentration is similar to that of E. coli .