2062-78-4
2062-78-4 结构式
基本信息
哌莫奇特
匹莫奇特
匹莫齐特
PIMOZIDE
1-(1-(4,4-bis(p-fluorophenyl)butyl)-4-piperidyl)-2-benzimidazolinon
1-(1-(4,4-bis(p-fluorophenyl)butyl)-4-piperidyl)-2-benzimidazolinone
1-(4,4-bis(p-fluorophenyl)butyl)-4-(2-oxo-1-benzimidazolinyl)piperidine
mcn-jr-6238
orap
3-(1-(4,4-bis(4-fluorophenyl)butyl)-4-piperidyl)-1H-benzimidazol-2-one
2H-Benzimidazol-2-one, 1-1-4,4-bis(4-fluorophenyl)butyl-4-piperidinyl-1,3-dihydro-
OPIRAN
1-[1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazole-2-one
1-[1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidyl]-1,3-dihydro-2H-benzimidazol-2-one
R 6238
物理化学性质
常见问题列表
分子印迹技术是以待测目标分子为模板分子，将具有结构上互补的功能性单体通过共价或非共价键与模板分子结合形成单体模板分子复合物，再加入交联剂使之与单体进行聚合反应形成模板分子聚合物，反应完成后通过物理或化学方法去除模板分子，得到分子印迹聚合物，在聚合物中形成与原印迹分子空间结构互补并且具有多重识别位点的空穴
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STAT3
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STAT5
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Dopamine D2 receptor 1.4 nM (Ki) |
Dopamine D3 receptor 2.5 nM (Ki) |
Dopamine D1 receptor 588 nM (Ki) |
α1-adrenoceptor 39 nM (Ki) |
Pimozide is a dopamine receptor antagonist, with K i s of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively; also has affinity at α1-adrenoceptor and 5-HT1A, with K i s of 39 nM and 310 nM, respectively. Pimozide acts as an inhibitor of STAT3. Pimozide (0-15 μM) shows inhibitory of the proliferation of U2OS cells, with IC 50 value at 24, 48, and 72 h of 22.16 ± 2.54, 17.49 ± 1.14 and 13.78 ± 0.34 μM, respectively. Pimozide (10 μM) inhibits the colony- and sphere-forming abilities of osteosarcoma cells. Pimozide (15 μM) induces G0/G1 phase cell cycle arrest, suppresses the extracellular signal-regulated kinase (Erk) signaling to inhibit cell viability, and produces ROS generation through inhibiting antioxidant enzyme gene catalase expression in osteosarcoma cells. Pimozide acts as an inhibitor of STAT5. Pimozide reduces the expression of endogenous STAT5 target genes, and decreases STAT5 tyrosine phosphorylation.