2797-51-5
中文名称
2-氨基-3-氯-1,4-萘醌
英文名称
2-AMINO-3-CHLORO-1,4-NAPHTHOQUINONE
CAS
2797-51-5
EINECS 编号
220-529-2
分子式
C10H6ClNO2
MDL 编号
MFCD00001680
分子量
207.61
MOL 文件
2797-51-5.mol
更新日期
2023/03/20 19:41:19
2797-51-5 结构式
基本信息
中文别名
2-氨基-3-氯-1,4-萘醌灭藻醌
英文别名
2-AMINO-3-CHLORO-1,4-NAPHTHOQUINONE2-AMINO-3-CHLORO-1,4-NAPHTOQUINONE
ACN
ASISCHEM T86788
MOGETON
QUINOCLAMIN
QUINOCLAMINE
TIMTEC-BB SBB008204
06k
06k-50w
06K-Quinone
1,4-Naphthoquinone, 2-Amino-3-chloro-
2-amino-3-chloro-4-naphthalenedione
2-amino-3-chloro-4-naphthoquinone
2-Amino-3-Chloronaphthoquinone
2-Chloro-3-amino-1,4-naphthoquinone
3-Chloro-2-amino-1,4-naphthoquinone
ACNQ
Mogeton G
Mogeton granule
所属类别
分析化学：农残、兽药及化肥类物理化学性质
熔点198-200 °C
沸点310℃
密度1.49
折射率1.5790 (estimate)
闪点141℃
储存条件0-6°C
溶解度DMSO: 250 mg/mL (1204.18 mM)
水溶解性不溶于水
酸度系数(pKa)0.70±0.20(Predicted)
形态粉末
颜色橙色
LogP2.120
安全数据
警示词警告
危险品标志T
危险类别码R36/37/38-R23-R22
安全说明S45-S37/39-S26
危险品运输编号UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany3
RTECS号QL7350000
危险等级6.1
海关编码29223990
毒性LD50 oral in rat: 1360mg/kg
2797-51-5(安全特性,毒性,储运)
储运特性
库房通风低温干燥; 与食品原料分开储运毒性分级
中毒急性毒性
口服- 大鼠 LD50: 1360 毫克/ 公斤; 口服- 小鼠 LD50: 1260 毫克/ 公斤可燃性危险特性
燃烧产生有毒氮氧化物和氯化物气体类别
农药灭火剂
干粉、泡沫、砂土知名试剂公司产品信息
Acros Organics
灭藻醌2-Amino-3-chloro-1,4-naphthoquinone(2797-51-5)
Sigma Aldrich
2797-51-5(sigmaaldrich)常见问题列表
生物活性
Quinoclamine 是一种萘醌衍生物，是一种 NF-κB 抑制剂。Quinoclamine 具有抗肿瘤活性。靶点
NF-κB
体外研究
Quinoclamine causes differentiation of U-937 cells into macrophage-like cells.
Quinoclamine inhibits NF-κB activities in HepG2 cells, with an IC
50
of 1.7 μM.
Quinoclamine (1-4 μM; 30 minutes ) suppresses endogenous NF-κB activity in HepG2 cells through the inhibition of IκB-α phosphorylation and p65 translocation.
Quinoclamine inhibits induced NF-κB activities in lung and breast cancer cell lines.
Quinoclamine affects the expression levels of genes involved in cell cycle or apoptosis.
Quinoclamine down-regulates the expressions of UDP glucuronosyltransferase genes involved in phase II drug metabolism.
Cell Viability Assay
| Cell Line: | HepG2 cells |
| Concentration: | 1 μM, 2 μM, 4 μM, 8 μM, 16 μM, 32 μM, 64 μM |
| Incubation Time: | 24 hours |
| Result: | Inhibited NF-κB activities in HepG2 cells. |
Western Blot Analysis
| Cell Line: | HepG2 cells |
| Concentration: | 0 μM, 1 μM, 2 μM, 4 μM |
| Incubation Time: | 30 minutes |
| Result: | Inhibited IκB-α phosphorylation and p65 translocation in HepG2 cells. |