35286-58-9
中文名称
苦丁冬青甙 H
英文名称
3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester
CAS
35286-58-9
分子式
C41H66O13
分子量
766.959
MOL 文件
35286-58-9.mol
更新日期
2024/04/25 13:34:06
35286-58-9 结构式
基本信息
中文别名
地榆皂苷I苦丁冬青苷H
地榆糖苷I)
苦丁冬青甙 H
苦丁冬青甙 I
地榆皂苷I对照品,
地榆皂苷I(标准品)
苦丁冬青苷H、苦丁冬青甙H
地榆皂苷I(苦丁冬青苷 H
苦丁冬青苷 H,苦丁冬青甙H,地榆糖苷I
英文别名
Gouguside 7Kudinoside H
Zigu-glucoside I
Ziyu-glycoside Ⅰ
Ulmus pumila saponin I
3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester
Urs-12-en-28-oic acid, 3-(α-L-arabinopyranosyloxy)-19-hydroxy-, β-D-glucopyranosyl ester, (3β)-
[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-1-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-10-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
所属类别
天然产物：萜类物理化学性质
外观性状白色结晶体，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于地榆。
熔点198-202 ºC
沸点841.9±65.0 °C(Predicted)
密度1.35
储存条件-20°C, protect from light
溶解度Soluble in acetonitrile and methanol;
酸度系数(pKa)12.52±0.70(Predicted)
形态粉末
颜色白色
水溶解性不溶于水
常见问题列表
概述
地榆皂苷I，英文名ziyu-glycoside I，是从蔷薇科地榆属植物地榆或长叶地榆的根中提取得到的有明显药理活性的化合物。生物活性
Ziyuglycoside I 从 S. officinalis 根中分离，具有抗皱活性，并增加 I 型胶原蛋白的表达。 Ziyuglycoside I 可用作化妆品的有效成分。Ziyuglycoside I 引发 p53 介导的细胞周期阻滞和凋亡 (apoptosis)，可用于三阴乳腺癌的相关研究。体外研究
Ziyuglycoside I (5-160 µM; 24 hours) reveals a marked anti-proliferation activity with an IC 50 value of 13.96 µM in MDA-MB-231 cells. Ziyuglycoside I (5-20 µM; 24 hours) induces MDA-MB-231 cell apoptosis by increasing the percentage of apoptotic cells from 2.43% to 44.76% at 20 µM. Ziyuglycoside I (5-20 µM; 24 hours) induces the cleavage of caspas-8, caspase-9, and caspase-3, up-regulates the pro-apoptotic protein Bax, and down-regulates anti-apoptotic protein Bal-2, dose-dependently reduces the level of mito-cyto c expression.
Cell Viability Assay
| Cell Line: | MDA-MB-231 cells |
| Concentration: | 5 µM, 10 µM, 20 µM, 40 µM, 80 µM, and 160 µM |
| Incubation Time: | 24 hours |
| Result: | Showed cytotoxicity on MDA-MB-231 cells. |
Cell Cycle Analysis
| Cell Line: | MDA-MB-231 cells |
| Concentration: | 5 µM, 10 µM, and 20 µM |
| Incubation Time: | 24 hours |
| Result: | Induced G2/M phase arrest and apoptosis on MDA-MB-231 Cells |
Western Blot Analysis
| Cell Line: | MDA-MB-231 cells |
| Concentration: | 5 µM, 10 µM, and 20 µM |
| Incubation Time: | 24 hours |
| Result: | Induced apoptosis in MDA-MB-231 Cells through Intrinsic and Extrinsic Pathways. |