41443-28-1
中文名称
1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮
英文名称
ODQ
CAS
41443-28-1
分子式
C9H5N3O2
MDL 编号
MFCD00792620
分子量
187.15
MOL 文件
41443-28-1.mol
更新日期
2024/04/30 10:32:13
41443-28-1 结构式
基本信息
中文别名
1H- [1,2,4]恶二唑[4,3-A]喹喔啉-1-酮1H-[1,2,4]噁二唑并[4,3-A]喹喔啉-1-酮
1H-[1,2,4]恶二唑并[4,3-A]喹喔啉-1-酮
1H-[1,2,4]恶二唑并[4,3-A]喹恶啉-1-酮
1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮
英文别名
ODQ 所属类别
有机原料：酮类化合物物理化学性质
熔点160-170 °C
熔点160-170 °C
沸点321.89°C (rough estimate)
密度1.3753 (rough estimate)
RTECS号RO0913150
折射率1.6500 (estimate)
储存条件2-8°C
储存条件2-8°C
溶解度ethanol: 1.2 mg/mL
溶解度乙醇：1.2 mg/mL
酸度系数(pKa)0.94±0.20(Predicted)
形态powder
形态粉末
颜色pale yellow
颜色淡黄色
稳定性DMSO中的溶液可在-20°下稳定储存3个月。
安全数据
常见问题列表
生物活性
ODQ (1H-ODQ) 是一种有效的和选择性的 soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) 的抑制剂，可增强顺铂在人类间皮瘤细胞中的促凋亡作用。靶点
| Target | Value |
|
sGC
() |
体外研究
At 30 and 50 μM, ODQ causes significant induction of apoptosis in the NCI-H2452 cells, elevating apoptotic levels by 12 fold and 15 fold, respectively. At 10μM, a concentration below the threshold for induction of apoptosis by ODQ, ODQ in combination with Cisplatin enhanced (in fact, doubled) the pro-apoptotic effects of Cisplatin at 1 μM.
体内研究
ODQ (2 mg/kg; i.p.) reduces the multiple organ injury and dysfunction caused by wall fragments of Gram-positive or Gram-negative bacteria in the anesthetized rat.
| Animal Model: | Anesthetized, male Wistar rats |
| Dosage: | 2 mg/kg |
| Administration: | I.p. |
| Result: | Attenuated the renal dysfunction, lung injury, and hepatocellular injury caused by lipoteichoic acid/peptidoglycan or lipopolysaccharide. |