4419-39-0
4419-39-0 结构式
基本信息
9α-氯-16β-甲基孕甾-1,4-二烯-11β,17α,21-三醇-3,20-二酮
倍氯米松
倍氯美松
9ALPHA-CHLORO-16BETA-METHYL-1,4-PREGNADIENE-11BETA,17ALPHA,21-TRIOL-3,20-DIONE
BECLOMETHASONE
9alpha-Chloro-16beta-methylprednisolone
9-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Chloro-11beta,17,21-trihydroxy-16beta-methyl-pregna-1,4-diene-3,20-dione
Beclometasone
Pregna-1,4-diene-3,20-dione, 9-chloro-11,17,21-trihydroxy-16-methyl-, (11beta,16beta)-
BeclomethasoneDipropionateBase
Beclomethasone Dipropionate 5534-09-8 /Base
9-Chloro-16-methylpregna-1,4-diene-11,17,21-triol-3,20-dione
Beclomethasone (base and/or unspecified salts)
(9-α-Chloro-16-beta-methylprednisolone)
(11,16)-9-Chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9a-Chloro-16-methylprednisolone
Becolvent
9α-Chloro-16β-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione, 9α-Chloro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione
物理化学性质
常见问题列表
Glucocorticoid Receptor
An inhibition of the normal physiological neutrophil migration and of neutrophil chemotaxis directed by wounding-induced inflammation is detected at 4 h after administration of 25 μM Beclomethasone. Tumour cell invasion and micrometastasis is also reduced in embryos incubated in 25 μM Beclomethasone 4 h before implantation. In addition, the lysyl oxidase inhibitor β-aminoproprionitrile (βAPN) largely reduces fibrillar collagen and enhances the CHT-TF transmigration of neutrophils, leading to a significant increase of tumour cell invasion and subsequent formation of micrometastases. Notably, βAPN inhibits neutrophil chemotaxis induced by inflammation, indicating that the increase of tumour cell invasion in βAPN-treated embryos is correlated with enhanced non-pathological neutrophil migration, but not with inflammation.