52-39-1
中文名称
醛固酮
英文名称
ALDOSTERONE
CAS
52-39-1
EINECS 编号
200-139-9
分子式
C21H28O5
MDL 编号
MFCD00051136
分子量
360.44
MOL 文件
52-39-1.mol
更新日期
2024/04/28 11:52:51
52-39-1 结构式
基本信息
中文别名
醛固酮醛固醇酮
醛甾酮
英文别名
11B-21-DIHYDROXY-3,20-DIOXO-4-PREGNAN-18-AL(11BETA)-11,21-DIHYDROXY-3,20-DIOXO-PREGN-4-EN-18-AL
11-BETA,18-EPOXY-18,21-DIHYDROXY-4-PREGNENE-3,20-DIONE
11BETA,21-DIHYDROXY-3,20-DIOXO-4-PREGNEN-18-AL
11BETA,21-DIHYDROXYPREGN-4-ENE-3,18,20-TRIONE
18-ALDOCORTICOSTERONE
18-KETOCORTICOSTERONE
4-PREGNEN-11-BETA, 21-DIOL-3,18,20-TRIONE
4-PREGNEN-11-BETA,21-DIOL-3,20-DIONE 18-AL
4-PREGNEN-18-AL-11B,21-DIOL-3,20-DIONE
4-PREGNEN-18-AL-11-BETA,21-DIOL-3,20-DIONE
ALDOSTERONE
ELECTROCORTIN
LECTROCORTIN
REICHSTEIN X
11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al
11beta,21-Dihydroxy-3,20-dioxo-pregn-4-en-18-al
18-Oxocorticosterone
21-dihydroxy-3,20-dioxo-1(11-beta)-pregn-4-en-18-a
21-dihydroxy-3,20-dioxo-1(11beta)-pregn-4-en-18-a
物理化学性质
外观性质醛甾酮属一种类固醇(steroid)激素，为人体盐水平衡调节剂(一种矿物类皮质激素，主要由肾上腺皮质球状带分泌。此外，心脏、脑、血管壁也能合成和分泌醛甾酮。微溶于水，溶于乙醇、醚和氯仿。[a]20/D:155° (c=0.1, CHCl3)
熔点170-172°C
比旋光度D23 +152.2° (anhydr; c = 2 in acetone); D25 +161° (c = 0.1 in chloroform)
沸点412.46°C (rough estimate)
密度1.28
折射率1.6120 (estimate)
闪点2℃
储存条件2-8°C
溶解度可溶于丙酮（轻微）、氯仿（轻微）、DMSO（轻微）、甲醇（轻微）
酸度系数(pKa)12.98±0.10(Predicted)
形态结晶粉末
颜色白色
水溶解性51.18mg/L(37 ºC)
Merck13,224
BRN3224996
EPA化学物质信息Aldosterone (52-39-1)
常见问题列表
生物活性
Aldosterone 是原发性盐皮质激素。Aldosterone 是一种类固醇激素，通过肾上腺皮质的肾小球区 (ZG) 对肾素-血管紧张素系统激活 (RAS) 或高钾饮食反应而合成和分泌。Aldosterone 活性在细胞水平上依赖于胞浆/核盐皮质激素受体 (MR) 的结合和激活。靶点
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Human Endogenous Metabolite
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体外研究
Aldosterone (1-1000 nM; 24 hours) inhibits interleukin-1β-stimulated nitrite production by vascular smooth muscle cells in a dose-dependent manner.
体内研究
Aldosterone (1 mg/Kg+1% NaCl; i.h.; once daily for 3 weeks) significantly increases systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP).
Aldosterone (0.72 mg/kg/day; 14 days) causes a small increase ( 14 mmHg) in blood pressure in male mice.
| Animal Model: | Forty male Wistar rats |
| Dosage: | 1 mg/Kg (+1% NaCl) |
| Administration: | i.h.; once daily for 3 weeks |
| Result: | Systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP) were significantly higher in aldosterone-salt-treated animals. |