53-41-8
53-41-8 结构式
基本信息
雄(甾)酮
雄甾酮,雄酮,雄性酮
3α-羟基-5α-雄甾烷-17-酮
雄甾酮
5Α-雄烷-3Α-醇-17-酮
男酯酮
顺式酮基化甾醇
顺式雄素酮
顺式雄酮
雄性酮
3ALPHA-HYDROXY-5ALPHA-ANDROSTAN-17-ONE
3-ALPHA-HYDROXYETIOALLOCHOLAN-17-ONE
5A-ANDROSTAN-3A-OL-17-ONE
5ALPHA-ANDROSTAN-3ALPHA-OL-17-ONE
5ALPHA-ANDROSTAN-3ALPHA-OL-17-ONE-16,16-D2
androstan-3a-ol-17-one
ANDROSTERINE
ANDROSTEROLONE
ANDROSTERONE
CIS-ANDROSTERONE
3-alpha-hydroxy-17-androstanone
3alpha-Hydroxy-17-androstanone
3-alpha-hydroxy-5-alpha-androstan-17-on
3-Epihydroxyetioallocholan-17-one
3-hydroxy-,(3-alpha,5-alpha)-androstan-17-on
3-hydroxy-,(3alpha,5alpha)-androstan-17-on
5alpha-Androstan-17-one, 3alpha-hydroxy-
5alpha-Androstane-3alpha-ol-17-one
5alpha-Androsterone
物理化学性质
安全数据
常见问题列表
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Human Endogenous Metabolite
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Androsterone activates both the mFXR-LBD and the hFXR-LBD, with Androsterone activating the mFXR-LBD more strongly than the hFXR-LBD. Furthermore, cotransfection studies with gal4-hFXR-LBD and SRC-1/VP16 expression plasmids demonstrate that Androsterone potentiates the interaction of SRC-1 with the hFXR-LBD. Several amino acid changes including H294S, S332V, R351H, and Y361F significantly reduce Androsterone activation. Androsterone (5α, 3α-A) (10 to 100 μM) also inhibits epileptiform discharges in a concentration-dependent fashion in the in vitro slice model.
Androsterone treatment results in a significant induction of small heterodimer partner (SHP), suggesting Androsterone may activate endogenous FXR. Intraperitoneal injection of Androsterone (5α, 3α-A) protects mice in a dose-dependent fashion from seizures in the following models (ED 50 , dose in mg/kg protecting 50% of animals): 6 Hz electrical stimulation (29.1), pentylenetetrazol (43.5), pilocarpine (105), 4-AP (215), and maximal electroshock (224).