6384-92-5
中文名称
N-甲基-D-天冬氨酸
英文名称
N-Methyl-D-aspartic acid
CAS
6384-92-5
EINECS 编号
227-012-0
分子式
C5H9NO4
MDL 编号
MFCD06795789
分子量
147.13
MOL 文件
6384-92-5.mol
更新日期
2024/04/26 10:49:42
6384-92-5 结构式
基本信息
中文别名
(R)-2-(甲基氨基)丁二酸N-甲基-D-天冬氨酸
N-甲基-D-天门冬胺基乙酸
N-甲基-D-天(门)冬氨酸
英文别名
H-D-MEASP-OHH-D-MEASP-OH HCL
N-ALPHA-METHYL-D-ASPARTIC ACID
N-ALPHA-METHYL-D-ASPARTIC ACID HYDROCHLORIDE
NMDA
N-ME-D-ASPARTIC ACID
N-ME-D-ASP-OH
N-ME-D-ASP-OH HCL
N-METHYL-D-ASPARAGINIC ACID
N-METHYL-D-ASPARTIC ACID
N-METHYL-D-ASPARTIC ACID HYDROCHLORIDE
[R]-2-[METHYLAMINO]SUCCINIC ACID
n-methylaspartate
n-methyl-d-aspartate
n-methyl-d-asparticaci
N-Methyl D-artic acid.
(2R)-2-methylaminobutanedioic acid
(R)-2-(Methylamino)succinic acid, NMDA
(R)-2-(Methylamino)butanedioic acid
N-Methyl-D-Asp-OH
所属类别
生物化工：天冬氨酸类衍生物物理化学性质
熔点187-192 °C
熔点187-192 °C
比旋光度-28 º (c=1, HCl 6N)
沸点267.21°C (rough estimate)
密度1.4285 (rough estimate)
折射率-15 ° (C=2, H2O)
储存条件Sealed in dry,Room Temperature
储存条件Store at RT.
溶解度可溶于酸性水溶液（少许）、DMSO（少许）、水（少许）
酸度系数(pKa)2.21±0.23(Predicted)
形态solid
颜色white
水溶解性微溶
敏感性吸湿性
Merck14,6662
Merck6662
BRN1724431
LogP1.390 (est)
安全数据
警示词危险
危险性描述H319-H400-H372
安全说明22-24/25
安全说明S22-S24/25
WGK Germany3
WGK Germany3
RTECS号CI9457000
F10
海关编码29225090
知名试剂公司产品信息
Acros Organics
N-甲基-D-天门冬氨酸N-Methyl-D-aspartic acid, 98%(6384-92-5)
Sigma Aldrich
6384-92-5(sigmaaldrich)N-甲基-D-天冬氨酸价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-17551 | N-甲基-D-天冬氨酸 NMDA | 6384-92-5 | 50mg | 465元 |
| 2024/01/25 | HY-17551 | N-甲基-D-天冬氨酸 NMDA | 6384-92-5 | 100mg | 744元 |
| 2024/01/16 | C32919 | N-甲基-D-天冬氨酸 1GR N-Methyl-D-aspartic acid, 98% | 6384-92-5 | 50mg | 1071元 |
常见问题列表
生物活性
NMDA (N-Methyl-D-aspartic acid)是一种特异性NMDA受体激动剂，通常作为受体，模拟神经递质谷氨酸的活性。Phase 4。靶点
| Target | Value |
| NMDA receptor |
体外研究
NMDA是兴奋性氨基酸神经递质，只与NMDA受体结合，而不会影响其他谷氨酸受体（如AMPA和Kainate)。NMDA特异性与NMDA受体的NR2亚基结合，刺激非特异性阳离子通道的打开，使Ca
体内研究
NMDA (0.2 nM) shows significant effects on MF, IF, IL, and EL, respectively, decreasing the mount and intromission frequencies, and shortening the intromission and ejaculation latencies. NMDA and AP-5 significantly, respectively, facilitates and inhibits the ejaculatory behavior during the copulation testing 30 min. Bilateral microinjection of NMDA into PVN significantly increases the baseline LSNA, the peaking increment of LSNA occurred within 5 min from the time of NMDA microinjected into PVN.