74536-44-0
基本信息
维生素 B6 焦谷氨酸盐
METADOXINE
Metadoxil
Metadoxine(Pyridoxine Pyroglutamate)
METADOXINE(FORR&DONLY)
5-Hydroxy-6-methyl-3,4-pyridinedimethanol, 5-Oxo-L-proline
Metasin
常见问题列表
美他多辛最早由意大利LABORATORI BALDACCI S.P.A.公司研制开发,临床主要用于急、慢性酒精中毒和酒精性脂肪肝的治疗,也被认为可以有效的戒酒,减少对酒精的依赖,改善记忆功能,特别是短时记忆。
将22.68g L-焦谷氨酸(0.176mol)与29.70g维生素B6碱(0.176mol)混合均匀,此过程中没有发粘,一直为干粉状。将此混合粉末放入150ml反应瓶中,然后搅拌下加入40ml异丙醇,异丙醇中含有1.5ml去离子水(其中异丙醇的比重 为0.7851),35℃水浴下搅拌2小时,保温35℃静置15小时。然后过滤,将所得白色固体在35℃下真空干燥4小时,研细,过80目筛,再在35℃下真空干燥5 小时,即得45.00g白色固体,产物为美他多辛,收率为85.9%。
Simultaneous Metadoxine treatment notably inhibits adipogenic differentiation in a dose-dependent manner. Metadoxine treatment from day 4 through day 8 is required for inhibition of MDI-induced preadipocyte differentiation. Metadoxine prevents glutathione depletion and the increase in lipid peroxidation damage caused by ethanol and acetaldehyde in HepG2 cells. In hepatic stellate cells, Metadoxine prevents the increase in collagen and attenuated TNF-α secretion caused by acetaldehyde. Thus, Metadoxine could be useful in preventing the damage produced in early stages of alcoholic liver disease as it prevents the redox imbalance of the hepatocytes and prevents TNF-α induction, one of the earliest events in hepatic damage.