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8048-52-0

中文名称 吖啶黄
英文名称 ACRIFLAVINE
CAS 8048-52-0
分子式 C27H25ClN6
MDL 编号 MFCD00064307
分子量 468.98
MOL 文件 8048-52-0.mol
更新日期 2024/04/30 11:25:26
8048-52-0 结构式 8048-52-0 结构式

基本信息

中文别名
吖啶黄素
吖啶黄
吖黄素
吖啶黃素
英文别名
2,8-DIAMINO-10-METHYLACRIDINIUM CHLORIDE
3,6-DIAMINO-10-METHYLACRIDINIUM CHLORIDE
ACRIFLAVINE
ACRIFLAVINE BASE
ACRIFLAVINE NEUTRAL
CI 46000
CI NO 46000
EUFLAVIN
EUFLAVINE
TRYPAFLAVINE
TRYPAFLAVINE FS
XANTHACRIDINE
2,8-diamino-10-methylacridiniumchloridemixturewith2,8-diaminoacridine
3,6-diamino-10-methylacridiniumchloridemixturewith3,6-acridinediamine
3,6-diaminoacridinemixturewith3,6-diamino-10-methylacridiniumchloride
acridinium,3,6-diamino-10-methyl-,chloridemixedwith3,6-acridinediamine
angiflan
assiflavine
bialflavina
bioacridin
所属类别
原料药:消毒防腐药

物理化学性质

熔点179-181 °C
沸点612.69°C (rough estimate)
密度1.0933 (rough estimate)
折射率1.6000 (estimate)
储存条件-20°C储存
溶解度在水中的溶解度为0.33g/mL(lit.)(lit.)
形态粉末
颜色深橙色至棕红色
Merck123
EPA化学物质信息Xanthacridinum (8048-52-0)

安全数据

危险性符号(GHS)
GHS07
警示词警告
危险性描述H302-H315-H319-H335
危险品标志Xn,N
危险类别码R22-R37/38-R41-R50/53
安全说明S26-S39-S60-S61
危险品运输编号UN 3077 9/PG 3
WGK Germany3
RTECS号AR9660000
海关编码29339900

应用领域

用途一
添加于李氏菌增菌肉汤基础中。
吖啶黄价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/04/30C21140吖啶黄
Acriflavine neutral, 13.3-15.8% chlorine
8048-52-025g726元
2024/04/30C21140吖啶黄
Acriflavine neutral, 13.3-15.8% chlorine
8048-52-0100g2047元
2024/04/30A0134吖啶黄素(3,6-二氨基-10-甲基吖啶盐酸盐和3,6-二氨基吖啶的混合物)
Acriflavine  (mixture of 3,6-Diamino-10-methylacridinium Chloride and 3,6-Diaminoacridine)
8048-52-025G420元

常见问题列表

生物活性
Acriflavine是用于标记高分子量RNA的荧光染料。它也是一种局部防腐剂。
体外研究

Acriflavine is identified as a potent inhibitor of the MCT4 that can inhibit the binding between Basigin and MCT4. Acriflavine significantly inhibits growth and self-renewal potential of several glioblastoma neurosphere lines. The HIF-1 inhibitor acriflavine decreases survival and growth of CML cells. It targets stem cell potential of CML cells.

体内研究

Acriflavine treatment inhibits intratumoral expression of VEGF and tumor vascularization. In a murine CML model, acriflavine decreases leukemia development and reduces LSC maintenance. Acriflavine retards tumor growth in a murine model of breast cancer. The combination of sunitinib with acriflavine significantly decreases vascular endothelial growth factor and TGF-β expression and reduces tumor vasculature followed by increased intratumor necrosis and apoptosis.

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