91917-65-6
中文名称
RO 15-4513
英文名称
RO 15-4513
CAS
91917-65-6
分子式
C15H14N6O3
分子量
326.31
MOL 文件
91917-65-6.mol
更新日期
2023/03/20 15:41:21
91917-65-6 结构式
基本信息
中文别名
化合物 T16775 英文别名
RO 15-4513Azidomazenil
Ro15 4513,Ro154513,Ro-15-4513
RO 15-4513 ETHANOL ANTAGONIST
Ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-1,4-benzodiazepine-3-carboxylate
ETHYL 8-AZIDO-6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]-[1,4]BENZODIAZEPINE-3-CARBOXYLATE
8-Azido-5,6-dihydro-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester
4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-6-oxo-, ethyl ester
8-AZIDO-5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID ETHYL ESTER
4H-Imidazo(1,5-A)(1,4)benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-5-methyl-6-oxo-, ethyl ester
物理化学性质
储存条件Desiccate at +4°C
溶解度45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.8 mg/mL
溶解度45%(w/v)aq2-羟丙基-β-环糊精：0.8 mg/mL
形态solid
颜色tan
CAS 数据库91917-65-6
常见问题列表
生物活性
Ro15-4513 是咪唑并苯二氮酮衍生物，是苯二氮卓受体 (BZR) 的部分反向激动剂。Ro15-4513 是有效的乙醇 (ethanol) 拮抗剂。Ro15-4513 具有抗焦虑作用。靶点
BZR; ethanol;
体外研究
Ro15-4513 usually acts as a partial inverse agonist at GABA A receptors, except an agonist for α4 and α6 subunit-containing ones.
体内研究
Ro 15-4513 (i.p.; 3 mg/kg; 10 min before being tested) completely inhibits the ethanol-induced (1.8 g/kg) reduction in total locomotor activity and partly the reduction in rearing.
Ro 15-4513 (i.p.; 3 mg/kg; 15 min before administration of 1.5 g/kg ethanol) reverses ethanol-induced sedation in GABA
A
receptor δ subunit-deficient mice.
| Animal Model: | Male C57BL/6J mice |
| Dosage: | 3 mg/kg |
| Administration: | I.p.; 10 min before being tested |
| Result: | Completely inhibited the ethanol-induced reduction in total locomotor activity and partly the reduction in rearing. |