3-[(2,7-二甲氧基吖啶-9-基)硫基]丙胺
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- CAS号:
- 184582-62-5
- 英文名:
- LDN-192960
- 英文别名:
- CS-613;LDN-192960;LDN-192960 2HCl;LDN-192960 dihydrochloride;1-Propanamine, 3-[(2,7-dimethoxy-9-acridinyl)thio]-;LDN-192960 3-(2,7-diMethoxyacridin-9-ylthio)propan-1-aMine;3-[(2,7-Dimethoxyacridin-9-yl)thio]propan-1-amine dihydrochloride;3-[(2,7-Dimethoxy-9-acridinyl)thio]-1-propanamine dihydrochloride;DYRK,Dual specificity tyrosine regulated kinase,Inhibitor,Dual specificity tyrosine phosphorylation regulated kinase,LDN-192960,LDN 192960,Haspin Kinase,LDN192960,inhibit
- 中文名:
- 3-[(2,7-二甲氧基吖啶-9-基)硫基]丙胺
- 中文别名:
- 化合物LDN-192960;HASPIN抑制剂(LDN-192960);3-[(2,7-二甲氧基吖啶-9-基)硫基]丙胺;3-(2,7-二甲氧基AC啶-9-基硫基)丙-1-胺;3-[(2,7-二甲氧基吖啶-9-基)硫基]丙-1-胺
- CBNumber:
- CB02642792
- 分子式:
- C18H20N2O2S
- 分子量:
- 328.43
- MOL File:
- 184582-62-5.mol
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3-[(2,7-二甲氧基吖啶-9-基)硫基]丙胺化学性质
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沸点:
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536.1±40.0 °C(Predicted)
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密度:
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1.25±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: soluble20mg/mL, clear
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酸度系数(pKa):
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9.33±0.10(Predicted)
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形态:
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powder
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颜色:
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white to light brown
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3-[(2,7-二甲氧基吖啶-9-基)硫基]丙胺性质、用途与生产工艺
LDN-192960 是 Haspin 和 DYRK2 的双重抑制剂，IC50 值分别为 10 nM 和 48 nM。
IC50: 10 nM (Haspin); 48 nM (DYRK2)
LDN-192960 (10 μM) is selective and inhibits ten of the other kinases by ≥90%, with only five being potently inhibited (IC
50
<1 μM), including CLK1 (IC
50
=0.21 μM), DYRK1A (IC
50
= 0.10 μM), DYRK2 (IC
50
=2 nM), DYRK3 (IC
50
=19 nM) and PIM1 (IC
50
=0.72 μM).LDN-0192960 (0-5 μM; 2 hours) demonstrates that the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells overexpressing Haspin with an EC
50
of 1.17 μM.LDN-0192960 (0-1 μM; 1 hour incubation in the presence of nocodazole and MG132) demonstrates the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells synchronized in mitosis with an EC
50
of 0.02 μM.
3-[(2,7-二甲氧基吖啶-9-基)硫基]丙胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-13455 | LDN-192960 | | 1 mg | 1333元 |
| 2024/04/30 | HY-13455 | 3-[(2,7-二甲氧基吖啶-9-基)硫基]丙胺
LDN-192960 | 184582-62-5 | 5mg | 2000元 |
3-[(2,7-二甲氧基吖啶-9-基)硫基]丙胺
生产厂家
184582-62-5, 3-[(2,7-二甲氧基吖啶-9-基)硫基]丙胺 相关搜索:
- 其它
- 细胞生物学试剂
- 化合物LDN-192960
- 3-(2,7-二甲氧基AC啶-9-基硫基)丙-1-胺
- 3-[(2,7-二甲氧基吖啶-9-基)硫基]丙-1-胺
- HASPIN抑制剂(LDN-192960)
- 3-[(2,7-二甲氧基吖啶-9-基)硫基]丙胺
- 184582-62-5
- DYRK,Dual specificity tyrosine regulated kinase,Inhibitor,Dual specificity tyrosine phosphorylation regulated kinase,LDN-192960,LDN 192960,Haspin Kinase,LDN192960,inhibit
- CS-613
- 1-Propanamine, 3-[(2,7-dimethoxy-9-acridinyl)thio]-
- LDN-192960 2HCl
- LDN-192960 dihydrochloride
- 3-[(2,7-Dimethoxyacridin-9-yl)thio]propan-1-amine dihydrochloride
- 3-[(2,7-Dimethoxy-9-acridinyl)thio]-1-propanamine dihydrochloride
- LDN-192960 3-(2,7-diMethoxyacridin-9-ylthio)propan-1-aMine
- LDN-192960