3-[(2,7-二甲氧基吖啶-9-基)硫基]丙胺
中文名称 | 3-[(2,7-二甲氧基吖啶-9-基)硫基]丙胺 |
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中文同义词 | 3-[(2,7-二甲氧基吖啶-9-基)硫基]丙胺;HASPIN抑制剂(LDN-192960);3-[(2,7-二甲氧基吖啶-9-基)硫基]丙-1-胺;3-(2,7-二甲氧基AC啶-9-基硫基)丙-1-胺;化合物LDN-192960 |
英文名称 | LDN-192960 |
英文同义词 | LDN-192960;LDN-192960 3-(2,7-diMethoxyacridin-9-ylthio)propan-1-aMine;3-[(2,7-Dimethoxy-9-acridinyl)thio]-1-propanamine dihydrochloride;3-[(2,7-Dimethoxyacridin-9-yl)thio]propan-1-amine dihydrochloride;LDN-192960 dihydrochloride;LDN-192960 2HCl;1-Propanamine, 3-[(2,7-dimethoxy-9-acridinyl)thio]-;CS-613 |
CAS号 | 184582-62-5 |
分子式 | C18H20N2O2S |
分子量 | 328.43 |
EINECS号 | |
相关类别 | 细胞生物学试剂;其它 |
Mol文件 | 184582-62-5.mol |
结构式 |
3-[(2,7-二甲氧基吖啶-9-基)硫基]丙胺 性质
沸点 | 536.1±40.0 °C(Predicted) |
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密度 | 1.25±0.1 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | 在DMSO中的溶解度为20mg/mL,澄清 |
酸度系数(pKa) | 9.33±0.10(Predicted) |
形态 | 粉末 |
颜色 | 白色至浅棕色 |
IC50: 10 nM (Haspin); 48 nM (DYRK2)
LDN-192960 (10 μM) is selective and inhibits ten of the other kinases by ≥90%, with only five being potently inhibited (IC 50 <1 μM), including CLK1 (IC 50 =0.21 μM), DYRK1A (IC 50 = 0.10 μM), DYRK2 (IC 50 =2 nM), DYRK3 (IC 50 =19 nM) and PIM1 (IC 50 =0.72 μM).LDN-0192960 (0-5 μM; 2 hours) demonstrates that the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells overexpressing Haspin with an EC 50 of 1.17 μM.LDN-0192960 (0-1 μM; 1 hour incubation in the presence of nocodazole and MG132) demonstrates the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells synchronized in mitosis with an EC 50 of 0.02 μM.
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-13455 | LDN-192960 | 1 mg | 1333元 | |
2024/04/30 | HY-13455 | 3-[(2,7-二甲氧基吖啶-9-基)硫基]丙胺 LDN-192960 | 184582-62-5 | 5mg | 2000元 |